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FASN3 Fatty acid synthase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355111, updated on 10-May-2024

Summary

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Official Symbol
FASN3provided by FlyBase
Official Full Name
Fatty acid synthase 3provided by FlyBase
Primary source
FLYBASE:FBgn0287184
Locus tag
Dmel_CG17374
See related
AllianceGenome:FB:FBgn0287184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
80Ff; CG17374; Dmel\CG17374; DM_7289423; FAS; fasn3; FASN[CG17374]; FAS[CG17374]; l(3)80Ff; l(3)Lh4B; l4B
Summary
Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity; oxidoreductase activity; and phosphopantetheine binding activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in adult head; adult heart; adult oenocyte; and spermatozoon. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See FASN3 in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25752859..25762779, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (1135558..1145478, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene loss of visual transmission Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45180 Neighboring gene antisense RNA:CR45182 Neighboring gene lethal (3) 80Fg Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A single gene affects both ecological divergence and mate choice in Drosophila. Chung H, et al. Science, 2014 Mar 7. PMID 24526311
  2. Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity. Garrido D, et al. PLoS Genet, 2015 Feb. PMID 25692475, Free PMC Article
  3. HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. Lin CH, et al. PLoS One, 2012. PMID 22761891, Free PMC Article
  4. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Storelli G, et al. Dev Cell, 2019 Jan 28. PMID 30554999, Free PMC Article
  5. Transcriptional Control of Quality Differences in the Lipid-Based Cuticle Barrier in Drosophila suzukii and Drosophila melanogaster. Wang Y, et al. Front Genet, 2020. PMID 32849846, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables [acyl-carrier-protein] S-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fatty acid synthase 3
Names
CG17374-PC
FASN3-PC
lethal (3) 80Ff
lethal 4B
lethal4B
NP_001015405.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    25752859..25762779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015405.4 → NP_001015405.3  fatty acid synthase 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015405.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PLB8
    Conserved Domains (12) summary
    cd05195
    Location:1443 → 1734
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:1761 → 1988
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:2000 → 2067
    PKS_PP; Phosphopantetheine attachment site
    smart00825
    Location:21 → 421
    PKS_KS; Beta-ketoacyl synthase
    smart00829
    Location:1443 → 1734
    PKS_ER; Enoylreductase
    COG0596
    Location:2120 → 2371
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cd00833
    Location:19 → 421
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam16197
    Location:383 → 492
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:877 → 1076
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl08282
    Location:517 → 831
    Acyl_transf_1; Acyl transferase domain
    cl21454
    Location:1301 → 1411
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl21494
    Location:2120 → 2375
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7PLB8 Q7PLB8
Q8MZH8 Q8MZH8

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