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kl-2 male fertility factor kl2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355181, updated on 5-Jan-2022

Summary

Official Symbol
kl-2provided by FlyBase
Official Full Name
male fertility factor kl2provided by FlyBase
Primary source
FLYBASE:FBgn0001313
Locus tag
Dmel_CG17866
Gene type
protein coding
RNA name
male fertility factor kl2
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17866; CG40438; DHC3A; Dmel\CG17866; kl2; Lms2
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of dynein complex. Predicted to be active in axoneme and motile cilium. Is expressed in adult head. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See kl-2 in Genome Data Viewer
Location:
h10-h11
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) Y NC_024512.1 (573088..664173)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) YHet NW_001848860.1 (81209..148249)

Chromosome Y - NC_024512.1Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene male fertility factor kl3 Neighboring gene Aldehyde reductase Y Neighboring gene ncRNA

Genomic regions, transcripts, and products

General gene information

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables minus-end-directed microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of dynein complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
male fertility factor kl2
Names
1beta-dynein heavy chain
CG17866-PD
kl-2-PD
male fertility factor kl-2
NP_001015505.5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_024512.1 Reference assembly

    Range
    573088..664173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015505.5NP_001015505.5  male fertility factor kl2 [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5LJP0
    Related
    FBpp0312333, FBtr0346722
    Conserved Domains (6) summary
    pfam03028
    Location:37604447
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:178749
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12441646
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30433373
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34023618
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:17852015
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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