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mpx myeloid-specific peroxidase [ Danio rerio (zebrafish) ]

Gene ID: 337514, updated on 30-Mar-2024

Summary

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Official Symbol
mpxprovided by ZNC
Official Full Name
myeloid-specific peroxidaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9460
See related
Ensembl:ENSDARG00000019521 AllianceGenome:ZFIN:ZDB-GENE-030131-9460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
drf; mpo; fj80f04; wu:fj80f04
Summary
Enables peroxidase activity. Acts upstream of or within inflammatory response; regulation of hydrogen peroxide metabolic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pleuroperitoneal region; and post-vent region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 10
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (7778870..7786020, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (7787705..7827254, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 24 Neighboring gene lysyl oxidase a Neighboring gene surfactant protein Ba Neighboring gene methionine adenosyltransferase 2Aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Warkentin AA, et al. Elife, 2014 Dec 22. PMID 25531068, Free PMC Article
  2. Using modified whole-mount in situ hybridization to study mpo expression in zebrafish. Shen LJ, et al. Exp Ther Med, 2013 Apr. PMID 23599728, Free PMC Article
  3. Broad-host-range plasmids for red fluorescent protein labeling of gram-negative bacteria for use in the zebrafish model system. Singer JT, et al. Appl Environ Microbiol, 2010 Jun. PMID 20363780, Free PMC Article
  4. Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. Mathias JR, et al. J Leukoc Biol, 2006 Dec. PMID 16963624
  5. Study on Anti-Inflammatory Effect and Major Anti-Inflammatory Components of PSORI-CM02 by Zebrafish Model. Yuan X, et al. Evid Based Complement Alternat Med, 2020. PMID 32595728, Free PMC Article

See all (446) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When infiltrated with Candida albicans, smu681 myeloperoxidase-deficient embryos and sibling embryos showed similar survival. Proliferation of C. albicans was more rapid in smu681 embryos than in sibling embryos, although it was eventually suppressed.
    Title: Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans.
  2. mpx expression is controlled differently in the anterior lateral plate mesoderm and posterior lateral plate mesoderm regions and describe novel roles for etv2 and gata1 during primitive neutropoiesis.
    Title: Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish.
  3. myeloperoxidase and H2O2 interact directly within neutrophils at the tissue wound
    Title: Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables lactoperoxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eosinophil peroxidase
Names
myeloperoxidase
unm t30963
unm_sm681
unm_t30963
NP_001338766.1
NP_997944.2
XP_021334788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351837.1 → NP_001338766.1  eosinophil peroxidase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CU681843
    UniProtKB/TrEMBL
    A0A8M1P4H4, Q90XS6
    Related
    ENSDARP00000043960.6, ENSDART00000043961.8
    Conserved Domains (2) summary
    pfam00386
    Location:772 → 890
    C1q; C1q domain
    cl14561
    Location:160 → 726
    An_peroxidase_like; Animal heme peroxidases and related proteins

  2. NM_212779.2 → NP_997944.2  eosinophil peroxidase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CU681843
    UniProtKB/TrEMBL
    A0A8M1PIA8, F1Q944, Q90XS6
    Related
    ENSDARP00000103509.3, ENSDART00000111058.4
    Conserved Domains (1) summary
    cl14561
    Location:160 → 726
    An_peroxidase_like; Animal heme peroxidases and related proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    7778870..7786020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479113.1 → XP_021334788.1  eosinophil peroxidase isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q5S9, Q90XS6
    Conserved Domains (2) summary
    pfam00386
    Location:771 → 889
    C1q; C1q domain
    cl14561
    Location:159 → 725
    An_peroxidase_like; Animal heme peroxidases and related proteins
Nucleotide Protein Strain
Heading Accession and Version

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