U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TAS2R60 taste 2 receptor member 60 [ Homo sapiens (human) ]

Gene ID: 338398, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TAS2R60provided by HGNC
Official Full Name
taste 2 receptor member 60provided by HGNC
Primary source
HGNC:HGNC:20639
See related
Ensembl:ENSG00000185899 MIM:613968; AllianceGenome:HGNC:20639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2R56; T2R60
Summary
This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. [provided by RefSeq, Jul 2017]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TAS2R60 in Genome Data Viewer
Location:
7q35
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143443453..143444409)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144798817..144799773)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143140546..143141502)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143088659-143089259 Neighboring gene Sharpr-MPRA regulatory region 10434 Neighboring gene Sharpr-MPRA regulatory region 2529 Neighboring gene EPH receptor A1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143101922-143102436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143106021-143106633 Neighboring gene EPHA1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12322 Neighboring gene taste 2 receptor member 62 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:143169186-143170385 Neighboring gene taste 2 receptor member 41 Neighboring gene olfactory receptor family 2 subfamily R member 1, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Thalmann S, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23632330
  2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Conte C, et al. Cytogenet Genome Res, 2002. PMID 12584440
  3. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article
  4. The molecular receptive ranges of human TAS2R bitter taste receptors. Meyerhof W, et al. Chem Senses, 2010 Feb. PMID 20022913
  5. Receptors for bitter and sweet taste. Montmayeur JP, et al. Curr Opin Neurobiol, 2002 Aug. PMID 12139982

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC119154, MGC119155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
NOT enables bitter taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception of bitter taste NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
taste receptor type 2 member 60
Names
taste receptor type 2 member 56
taste receptor, type 2, member 60

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177437.1 → NP_803186.1  taste receptor type 2 member 60

    See identical proteins and their annotated locations for NP_803186.1

    Status: REVIEWED

    Source sequence(s)
    AY114094
    Consensus CDS
    CCDS5885.1
    UniProtKB/Swiss-Prot
    A4D2G8, P59551, Q645W8, Q7RTR7
    UniProtKB/TrEMBL
    Q50KC8
    Related
    ENSP00000327724.1, ENST00000332690.1
    Conserved Domains (1) summary
    cd15018
    Location:31 → 308
    7tm_TAS2R41-like; mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    143443453..143444409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654714.1 Reference GRCh38.p14 PATCHES

    Range
    62817..63773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    144798817..144799773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59551.1 GenPept UniProtKB/Swiss-Prot:P59551

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous