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Tmem132a transmembrane protein 132A [ Rattus norvegicus (Norway rat) ]

Gene ID: 338474, updated on 30-Sep-2021

Summary

Official Symbol
Tmem132aprovided by RGD
Official Full Name
transmembrane protein 132Aprovided by RGD
Primary source
RGD:727936
See related
EnsemblRapid:ENSRNOG00000021338
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gbp; Hspa5bp1
Summary
ER/Golgi protein that negatively regulates serum starvation-induced cell death in culture; may be involved in brain development [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 379.8), Lung (RPKM 173.5) and 9 other tissues See more
Orthologs
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Genomic context

See Tmem132a in Genome Data Viewer
Location:
1q43
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207507074..207518779, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226912562..226925023, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099989 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene uncharacterized LOC120099988 Neighboring gene Cd6 molecule Neighboring gene solute carrier family 15 member 3 Neighboring gene transmembrane protein 109 Neighboring gene pre-mRNA processing factor 19

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 132A
Names
GRP78-binding protein
HSPA5-binding protein 1
heat shock 70kDa protein 5 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178021.1NP_821140.1  transmembrane protein 132A precursor

    See identical proteins and their annotated locations for NP_821140.1

    Status: PROVISIONAL

    Source sequence(s)
    AY216677
    UniProtKB/Swiss-Prot
    Q80WF4
    Related
    ENSRNOP00000037012.3, ENSRNOT00000028971.5
    Conserved Domains (3) summary
    pfam15705
    Location:44167
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:832899
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:403744
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    207507074..207518779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231041.4XP_006231103.1  transmembrane protein 132A isoform X1

    Conserved Domains (3) summary
    pfam15705
    Location:44167
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:833900
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:404745
    TMEM132; Transmembrane protein family 132
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