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ppk7 pickpocket 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33886, updated on 10-May-2024

Summary

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Official Symbol
ppk7provided by FlyBase
Official Full Name
pickpocket 7provided by FlyBase
Primary source
FLYBASE:FBgn0031802
Locus tag
Dmel_CG9499
See related
AllianceGenome:FB:FBgn0031802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9499; Dmel\CG9499; Ppk7; PPK7
Summary
Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in embryonic/larval dorsal branch; embryonic/larval dorsal trunk; embryonic/larval transverse connective; and tracheal tip cell. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC4 (acid sensing ion channel subunit family member 4); and ASIC5 (acid sensing ion channel subunit family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ppk7 in Genome Data Viewer
Location:
26C3-26C3; 2-19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6352324..6354331, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6352324..6354331, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickpocket 14 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster. Harrison BR, et al. BMC Genomics, 2020 May 4. PMID 32366330, Free PMC Article
  2. Evolution of the Insect PPK Gene Family. Latorre-Estivalis JM, et al. Genome Biol Evol, 2021 Sep 1. PMID 34390578, Free PMC Article
  3. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Liu L, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12571352, Free PMC Article
  4. Contribution of Drosophila DEG/ENaC genes to salt taste. Liu L, et al. Neuron, 2003 Jul 3. PMID 12848938
  5. ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. Lu B, et al. PLoS Genet, 2012. PMID 22438833, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pickpocket 7
Names
CG9499-PA
ppk7-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6352324..6354331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135172.2 → NP_609016.2  pickpocket 7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609016.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86LH2, Q9VME9
    Conserved Domains (1) summary
    pfam00858
    Location:38 → 493
    ASC; Amiloride-sensitive sodium channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VME9 Q9VME9

Gene LinkOut

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