U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF181 zinc finger protein 181 [ Homo sapiens (human) ]

Gene ID: 339318, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF181provided by HGNC
Official Full Name
zinc finger protein 181provided by HGNC
Primary source
HGNC:HGNC:12971
See related
Ensembl:ENSG00000197841 MIM:606741; AllianceGenome:HGNC:12971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHZ181
Summary
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]
Expression
Ubiquitous expression in ovary (RPKM 3.5), thyroid (RPKM 2.6) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (34734243..34745378)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37277885..37289960)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35225148..35236283)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 2B member 1, pseudogene Neighboring gene secretoglobin family 1B member 1, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:35222265-35222475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35224273-35224790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10508 Neighboring gene uncharacterized LOC124904698 Neighboring gene zinc finger protein 599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14452 Neighboring gene uncharacterized LOC124904696

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a locus of zinc finger genes in human chromosome 19q13.1-q13.3 region by fluorescence in situ hybridization. Wang R, et al. Somat Cell Mol Genet, 1996 May. PMID 8914611
  2. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
  3. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article
  4. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
  5. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC44316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 181

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029997.4 → NP_001025168.2  zinc finger protein 181 isoform 1

    See identical proteins and their annotated locations for NP_001025168.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC020910, AI800428, AK297316, BC104759, DC299701, DC304794
    Consensus CDS
    CCDS32990.2
    UniProtKB/Swiss-Prot
    B7ZKX3, Q2M3W8, Q49A75
    Related
    ENSP00000420727.1, ENST00000492450.3
    Conserved Domains (3) summary
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:211 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001145665.2 → NP_001139137.1  zinc finger protein 181 isoform 2

    See identical proteins and their annotated locations for NP_001139137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1, and encodes a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AC020910, AI800428, AK297316, BC143442, DC299701, DC304794
    Consensus CDS
    CCDS46043.1
    UniProtKB/Swiss-Prot
    Q2M3W8
    UniProtKB/TrEMBL
    B4DM69
    Related
    ENSP00000419435.1, ENST00000459757.6
    Conserved Domains (6) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:210 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516 → 538
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:502 → 526
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    34734243..34745378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723183.4 → XP_006723246.1  zinc finger protein 181 isoform X1

    See identical proteins and their annotated locations for XP_006723246.1

    UniProtKB/Swiss-Prot
    B7ZKX3, Q2M3W8, Q49A75
    Conserved Domains (3) summary
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:211 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_047438747.1 → XP_047294703.1  zinc finger protein 181 isoform X3

  3. XM_017026739.3 → XP_016882228.1  zinc finger protein 181 isoform X2

    UniProtKB/Swiss-Prot
    Q2M3W8
    Conserved Domains (6) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:210 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516 → 538
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:502 → 526
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047438748.1 → XP_047294704.1  zinc finger protein 181 isoform X4

  5. XM_005258849.3 → XP_005258906.1  zinc finger protein 181 isoform X1

    See identical proteins and their annotated locations for XP_005258906.1

    UniProtKB/Swiss-Prot
    B7ZKX3, Q2M3W8, Q49A75
    Related
    ENSP00000376065.3, ENST00000392232.7
    Conserved Domains (3) summary
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:211 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463 → 483
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_005258851.4 → XP_005258908.1  zinc finger protein 181 isoform X3

    See identical proteins and their annotated locations for XP_005258908.1

    Conserved Domains (6) summary
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:207 → 535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:513 → 535
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:499 → 523
    zf-H2C2_2; Zinc-finger double domain

  7. XM_005258850.3 → XP_005258907.1  zinc finger protein 181 isoform X2

    See identical proteins and their annotated locations for XP_005258907.1

    UniProtKB/Swiss-Prot
    Q2M3W8
    Conserved Domains (6) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:210 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516 → 538
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:502 → 526
    zf-H2C2_2; Zinc-finger double domain

  8. XM_006723184.4 → XP_006723247.1  zinc finger protein 181 isoform X4

    Conserved Domains (6) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:206 → 534
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:512 → 534
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:498 → 522
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37277885..37289960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320816.1 → XP_054176791.1  zinc finger protein 181 isoform X1

  2. XM_054320821.1 → XP_054176796.1  zinc finger protein 181 isoform X3

  3. XM_054320818.1 → XP_054176793.1  zinc finger protein 181 isoform X2

  4. XM_054320824.1 → XP_054176799.1  zinc finger protein 181 isoform X4

  5. XM_054320815.1 → XP_054176790.1  zinc finger protein 181 isoform X1

  6. XM_054320820.1 → XP_054176795.1  zinc finger protein 181 isoform X3

  7. XM_054320817.1 → XP_054176792.1  zinc finger protein 181 isoform X2

  8. XM_054320823.1 → XP_054176798.1  zinc finger protein 181 isoform X4

  9. XM_054320819.1 → XP_054176794.1  zinc finger protein 181 isoform X3

  10. XM_054320822.1 → XP_054176797.1  zinc finger protein 181 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2M3W8.1 GenPept UniProtKB/Swiss-Prot:Q2M3W8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous