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Daao2 D-amino acid oxidase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33955, updated on 19-Jun-2024

Summary

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Official Symbol
Daao2provided by FlyBase
Official Full Name
D-amino acid oxidase 2provided by FlyBase
Primary source
FLYBASE:FBgn0031860
Locus tag
Dmel_CG11236
See related
AllianceGenome:FB:FBgn0031860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11236; daao; DAAO; DDO; Dmel\CG11236
Summary
Predicted to enable D-amino-acid oxidase activity. Predicted to be involved in D-amino acid catabolic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; embryonic midgut chamber; and embryonic/larval midgut. Orthologous to human DDO (D-aspartate oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Daao2 in Genome Data Viewer
Location:
27B3-27B3; 2-22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6803011..6804372)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6803011..6804372)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44081 Neighboring gene senseless-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of D-amino acids on sleep in Drosophila. Nakagawa H, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34922200
  2. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Dai X, et al. Nat Commun, 2019 May 7. PMID 31064979, Free PMC Article
  3. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, et al. Mol Metab, 2014 Feb. PMID 24567903, Free PMC Article
  4. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article
  5. Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. Parisi MJ, et al. BMC Genomics, 2010 Jun 1. PMID 20515475, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables D-amino-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-amino-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables D-amino-acid oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-amino acid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in D-amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
D-amino acid oxidase 2
Names
CG11236-PA
CG11236-PB
D-amino acid oxidase
Daao2-PA
Daao2-PB
NP_001245914.1
NP_609075.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6803011..6804372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135231.3 → NP_609075.1  D-amino acid oxidase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM80
    Related
    FBpp0078967
    Conserved Domains (1) summary
    pfam01266
    Location:4 → 325
    DAO; FAD dependent oxidoreductase

  2. NM_001258985.2 → NP_001245914.1  D-amino acid oxidase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDG8
    Conserved Domains (1) summary
    pfam01266
    Location:4 → 322
    DAO; FAD dependent oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDG8 M9NDG8
Q9VM80 Q9VM80

Gene LinkOut

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