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TRIML1 tripartite motif family like 1 [ Homo sapiens (human) ]

Gene ID: 339976, updated on 5-Mar-2024

Summary

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Official Symbol
TRIML1provided by HGNC
Official Full Name
tripartite motif family like 1provided by HGNC
Primary source
HGNC:HGNC:26698
See related
Ensembl:ENSG00000184108 AllianceGenome:HGNC:26698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF209
Summary
The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]
Expression
Restricted expression toward testis (RPKM 5.0) See more
Orthologs
mouse all
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Genomic context

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Location:
4q35.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (188137229..188150767)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (191484912..191498442)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (189060595..189068897)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif family like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189027714-189028231 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189028751-189029269 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189029270-189029788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189033421-189033938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189033939-189034456 Neighboring gene FAU pseudogene 3 Neighboring gene uncharacterized LOC107986337 Neighboring gene RNA, U6 small nuclear 173, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:189047967-189049166 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:189080404-189081603 Neighboring gene long intergenic non-protein coding RNA 2434 Neighboring gene uncharacterized LOC105377607

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1. Tian L, et al. Mol Reprod Dev, 2009 Jul. PMID 19156909
  2. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. Ji Y, et al. Br J Clin Pharmacol, 2014 Aug. PMID 24528284, Free PMC Article
  3. WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma. Li Y, et al. Cell Death Discov, 2022 Mar 9. PMID 35264565, Free PMC Article
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Woodsmith J, et al. Mol Cell Proteomics, 2012 Jul. PMID 22493164, Free PMC Article
  5. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This paper describes the mouse ortholog of the human TRIML1 gene.
    Title: Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36180, MGC138638, MGC138639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase TRIML1
Names
RING finger protein 209
RING-type E3 ubiquitin transferase TRIML1
NP_848651.2
XP_006714270.1
XP_011530221.1
XP_024309796.1
XP_054205900.1
XP_054205901.1
XP_054205902.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051631.1 RefSeqGene

    Range
    6253..14555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178556.5 → NP_848651.2  probable E3 ubiquitin-protein ligase TRIML1

    See identical proteins and their annotated locations for NP_848651.2

    Status: REVIEWED

    Source sequence(s)
    AK093499, BC015684, DB058735
    Consensus CDS
    CCDS3851.1
    UniProtKB/Swiss-Prot
    Q8N9V2, Q96BE5
    Related
    ENSP00000327738.3, ENST00000332517.4
    Conserved Domains (3) summary
    pfam10249
    Location:130 → 184
    NDUFB10; NADH-ubiquinone oxidoreductase subunit 10
    pfam15227
    Location:16 → 56
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd13733
    Location:287 → 462
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    188137229..188150767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454028.1 → XP_024309796.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

    Conserved Domains (1) summary
    cd13733
    Location:190 → 365
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  2. XM_011531919.2 → XP_011530221.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

    Conserved Domains (1) summary
    cd13733
    Location:190 → 365
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  3. XM_006714207.4 → XP_006714270.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X1

    Conserved Domains (3) summary
    pfam10249
    Location:130 → 184
    NDUFB10; NADH-ubiquinone oxidoreductase subunit 10
    pfam15227
    Location:16 → 56
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cl02614
    Location:287 → 414
    SPRY; SPRY domain

RNA

  1. XR_001741216.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    191484912..191498442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349927.1 → XP_054205902.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

  2. XM_054349926.1 → XP_054205901.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

  3. XM_054349925.1 → XP_054205900.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X1

RNA

  1. XR_008486977.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9V2.1 GenPept UniProtKB/Swiss-Prot:Q8N9V2

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