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MYLK4 myosin light chain kinase family member 4 [ Homo sapiens (human) ]

Gene ID: 340156, updated on 5-Jan-2022

Summary

Official Symbol
MYLK4provided by HGNC
Official Full Name
myosin light chain kinase family member 4provided by HGNC
Primary source
HGNC:HGNC:27972
See related
Ensembl:ENSG00000145949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SgK085
Summary
Predicted to enable myosin light chain kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in kidney (RPKM 1.8), thyroid (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See MYLK4 in Genome Data Viewer
Location:
6p25.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (2663629..2770376, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (2663871..2770610, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene GMDS divergent transcript Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 28 Neighboring gene long intergenic non-protein coding RNA 1600 Neighboring gene long intergenic non-protein coding RNA 2521 Neighboring gene Sharpr-MPRA regulatory region 3200 Neighboring gene Sharpr-MPRA regulatory region 3960 Neighboring gene Sharpr-MPRA regulatory region 6984 Neighboring gene WRN helicase interacting protein 1 Neighboring gene serpin family B member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin light chain kinase family member 4
Names
caMLCK like
sugen kinase 85
NP_001012418.2
NP_001334801.1
XP_005249135.2
XP_005249136.1
XP_006715145.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052793.1 RefSeqGene

    Range
    24409..111694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012418.5NP_001012418.2  myosin light chain kinase family member 4 isoform 1

    See identical proteins and their annotated locations for NP_001012418.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK096893, AK122581, AL138876, BU675945, BX647582
    Consensus CDS
    CCDS34330.1
    UniProtKB/Swiss-Prot
    Q86YV6
    Related
    ENSP00000274643.7, ENST00000274643.9
    Conserved Domains (2) summary
    smart00220
    Location:110361
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14193
    Location:101361
    STKc_MLCK4; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4
  2. NM_001347872.2NP_001334801.1  myosin light chain kinase family member 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in a distinct 5' UTR and use of an alternate start codon. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK122581, AL138876, AL139092, BU675945, BX647582
    UniProtKB/Swiss-Prot
    Q86YV6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    2663629..2770376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249078.4XP_005249135.2  myosin light chain kinase family member 4 isoform X1

  2. XM_005249079.2XP_005249136.1  myosin light chain kinase family member 4 isoform X2

    See identical proteins and their annotated locations for XP_005249136.1

    UniProtKB/Swiss-Prot
    Q86YV6
    Conserved Domains (2) summary
    smart00220
    Location:110361
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14193
    Location:101361
    STKc_MLCK4; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4
  3. XM_006715082.3XP_006715145.1  myosin light chain kinase family member 4 isoform X3

    Related
    ENSP00000494309.1, ENST00000647417.1
    Conserved Domains (2) summary
    smart00220
    Location:104355
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14193
    Location:95355
    STKc_MLCK4; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4

RNA

  1. XR_926185.3 RNA Sequence

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