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TREML1 triggering receptor expressed on myeloid cells like 1 [ Homo sapiens (human) ]

Gene ID: 340205, updated on 9-Aug-2021

Summary

Official Symbol
TREML1provided by HGNC
Official Full Name
triggering receptor expressed on myeloid cells like 1provided by HGNC
Primary source
HGNC:HGNC:20434
See related
Ensembl:ENSG00000161911 MIM:609714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
Summary
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Expression
Biased expression in bone marrow (RPKM 1.9), lymph node (RPKM 1.7) and 10 other tissues See more
Orthologs
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Genomic context

See TREML1 in Genome Data Viewer
Location:
6p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (41149097..41158450, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41116998..41122087, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene ADCY10 pseudogene 1 Neighboring gene uncharacterized LOC105375056 Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene uncharacterized LOC107986595

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of triggering receptor expressed on myeloid cells-like 1 (TREML1) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trem-like transcript 1 protein
Names
triggering receptor expressed on myeloid cells-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271807.1NP_001258736.1  trem-like transcript 1 protein isoform b precursor

    See identical proteins and their annotated locations for NP_001258736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL133404, AY358357, BQ023322, DW009745
    Consensus CDS
    CCDS64421.1
    UniProtKB/Swiss-Prot
    Q86YW5
    Related
    ENSP00000362219.4, ENST00000373127.8
    Conserved Domains (1) summary
    cl11960
    Location:25113
    Ig; Immunoglobulin domain
  2. NM_001271808.1NP_001258737.1  trem-like transcript 1 protein isoform c precursor

    See identical proteins and their annotated locations for NP_001258737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
    Source sequence(s)
    AL133404, AY358357, BC100946, BQ023322, DW009745
    Consensus CDS
    CCDS64420.1
    UniProtKB/Swiss-Prot
    Q86YW5
    Related
    ENSP00000400405.1, ENST00000437044.2
  3. NM_178174.4NP_835468.1  trem-like transcript 1 protein isoform a precursor

    See identical proteins and their annotated locations for NP_835468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL133404
    Consensus CDS
    CCDS4851.1
    UniProtKB/Swiss-Prot
    Q86YW5
    Related
    ENSP00000402855.2, ENST00000426005.6
    Conserved Domains (1) summary
    cl11960
    Location:25113
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    41149097..41158450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010824.1XP_016866313.1  trem-like transcript 1 protein isoform X2

    UniProtKB/Swiss-Prot
    Q86YW5
    Conserved Domains (1) summary
    cl11960
    Location:25113
    Ig; Immunoglobulin domain
  2. XM_017010825.1XP_016866314.1  trem-like transcript 1 protein isoform X3

  3. XM_017010822.1XP_016866311.1  trem-like transcript 1 protein isoform X1

  4. XM_017010823.1XP_016866312.1  trem-like transcript 1 protein isoform X2

    UniProtKB/Swiss-Prot
    Q86YW5
    Conserved Domains (1) summary
    cl11960
    Location:25113
    Ig; Immunoglobulin domain
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