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numb [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34263, updated on 11-Apr-2024

Summary

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Official Symbol
numbprovided by FlyBase
Primary source
FLYBASE:FBgn0002973
Locus tag
Dmel_CG3779
See related
AllianceGenome:FB:FBgn0002973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3779; d-numb; Dmel\CG3779; dNumb; l(2)03235; l(2)3235; l(2)s2201; N7-1; nb; Nb; Numb; NUMB; numbs
Summary
Enables Notch binding activity. Involved in several processes, including animal organ development; negative regulation of macromolecule metabolic process; and neurogenesis. Located in cell cortex. Is expressed in several structures, including ectoderm anlage; embryonic/larval circulatory system; extended germ band embryo; germ layer; and somatic precursor cell. Used to study brain cancer. Orthologous to human NUMB (NUMB endocytic adaptor protein) and NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
30B3-30B5; 2-35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9437469..9464184)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9437469..9464184)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene scattered Neighboring gene Ribosomal protein S28-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43769 Neighboring gene GDP dissociation inhibitor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reducing the expression of the Numb adaptor protein in neurons increases the searching behavior of Drosophila larvae. Galbraith A, et al. MicroPubl Biol, 2021. PMID 34327314, Free PMC Article
  2. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Li SC, et al. Proc Natl Acad Sci U S A, 1997 Jul 8. PMID 9207069, Free PMC Article
  3. Cell fate determination. When is a determinant a determinant? Cohen S, et al. Curr Biol, 1994 May 1. PMID 7922356
  4. The Multitasker Protein: A Look at the Multiple Capabilities of NUMB. Ortega-Campos SM, et al. Cells, 2023 Jan 15. PMID 36672267, Free PMC Article
  5. NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response. Xie X, et al. Int J Biol Sci, 2010 May 11. PMID 20567495, Free PMC Article

See all (539) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.
    Title: Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.
  2. Numb levels are upregulated to reinforce the bias of Notch signaling activation in the R3/R4 pair, two post-mitotic cells that are not specified by asymmetric cell division.
    Title: Regulation of Numb during planar cell polarity establishment in the Drosophila eye.
  3. condensed Numb and Pon complex has roles in phase transition during Drosophila neuroblast asymmetric division
    Title: Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
  4. Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain
    Title: Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain.
  5. Data suggest that Numb controls the balance between Notch receptor recycling and receptor targeting to late endosomes to regulate signaling output after asymmetric cell division in Drosophila neural progenitors.
    Title: Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells.
  6. The authors find that Numb is regulated in part through its asymmetric and symmetric distribution during stem cell divisions; however, its de novo synthesis is also required during the differentiation of the enteroendocrine cells.
    Title: Intrinsic regulation of enteroendocrine fate by Numb.
  7. Spdo is sorted toward late endosomes in a Numb-dependent manner.
    Title: A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo.
  8. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor.
    Title: Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor.
  9. Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila.
    Title: Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila.
  10. Data show regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
    Title: Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule tip cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic heart tube development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in enteroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pericardial nephrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ precursor cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ precursor cell fate determination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory organ precursor cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basal part of cell TAS
Traceable Author Statement
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
numb
Names
CG3779-PA
CG3779-PB
CG3779-PD
d-Numb
numb-PA
numb-PB
numb-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9437469..9464184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164855.2 → NP_723460.1  numb, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16554
    Related
    FBpp0079419
    Conserved Domains (2) summary
    cd01268
    Location:26 → 160
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:228 → 333
    NumbF; NUMB domain

  2. NM_001273362.1 → NP_001260291.1  numb, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260291.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8
    UniProtKB/TrEMBL
    M9PCN6
    Conserved Domains (2) summary
    cd01268
    Location:67 → 201
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:269 → 374
    NumbF; NUMB domain

  3. NM_078799.3 → NP_523523.2  numb, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523523.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8
    UniProtKB/TrEMBL
    M9PCN6
    Related
    FBpp0079420
    Conserved Domains (2) summary
    cd01268
    Location:67 → 201
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:269 → 374
    NumbF; NUMB domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCN6 M9PCN6
P16554.2 P16554

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