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Oatp30B Organic anion transporting polypeptide 30B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34268, updated on 4-Apr-2024

Summary

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Official Symbol
Oatp30Bprovided by FlyBase
Official Full Name
Organic anion transporting polypeptide 30Bprovided by FlyBase
Primary source
FLYBASE:FBgn0032123
Locus tag
Dmel_CG3811
See related
AllianceGenome:FB:FBgn0032123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3811; Dmel\CG3811; oatp 30B; oatp30B
Summary
Enables transmembrane transporter activity. Involved in organic substance transport. Located in basolateral plasma membrane. Is expressed in adult head; embryonic/larval proventriculus; eye disc; larval ventral nerve cord; and photoreceptor cell. Orthologous to several human genes including SLCO5A1 (solute carrier organic anion transporter family member 5A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
30B10-30B10; 2-35 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9521210..9540060)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9521210..9540060)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene GDP dissociation inhibitor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 30B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glial Chloride Channels in the Function of the Nervous System Across Species. Fernandez-Abascal J, et al. Adv Exp Med Biol, 2021. PMID 35138616
  2. Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides. Groen SC, et al. Insect Biochem Mol Biol, 2017 Feb. PMID 28011348, Free PMC Article
  3. Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Ayukawa T, et al. Cell Rep, 2014 Jul 24. PMID 24998533
  4. Essential functions of mosquito ecdysone importers in development and reproduction. Hun LV, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696563, Free PMC Article
  5. Glia ECM interactions are required to shape the Drosophila nervous system. Meyer S, et al. Mech Dev, 2014 Aug. PMID 24859129

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables active transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in organic substance transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic substance transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
organic anion transporting polypeptide 30B
Names
CG3811-PA
CG3811-PB
CG3811-PC
CG3811-PD
Oatp30B-PA
Oatp30B-PB
Oatp30B-PC
Oatp30B-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9521210..9540060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164857.3 → NP_723463.1  organic anion transporting polypeptide 30B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723463.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLB3
    Related
    FBpp0079423
    Conserved Domains (4) summary
    cd06174
    Location:174 → 433
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:633 → 684
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:171 → 818
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    cl21472
    Location:512 → 600
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_135449.4 → NP_609293.2  organic anion transporting polypeptide 30B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609293.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLB3
    Related
    FBpp0079424
    Conserved Domains (4) summary
    cd06174
    Location:174 → 433
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:633 → 684
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:171 → 818
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    cl21472
    Location:512 → 600
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. NM_205946.2 → NP_995668.1  organic anion transporting polypeptide 30B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLB3
    Conserved Domains (4) summary
    cd06174
    Location:174 → 433
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:633 → 684
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:171 → 818
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    cl21472
    Location:512 → 600
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  4. NM_205945.2 → NP_995667.1  organic anion transporting polypeptide 30B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTG4
    Conserved Domains (5) summary
    cd06174
    Location:113 → 372
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:572 → 623
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:110 → 757
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam04425
    Location:1054 → 1131
    Bul1_N; Bul1 N terminus
    cl21472
    Location:451 → 539
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTG4 Q7KTG4
Q8IH70 Q8IH70
Q9VLB3 Q9VLB3

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