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FCRL6 Fc receptor like 6 [ Homo sapiens (human) ]

Gene ID: 343413, updated on 5-Mar-2024

Summary

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Official Symbol
FCRL6provided by HGNC
Official Full Name
Fc receptor like 6provided by HGNC
Primary source
HGNC:HGNC:31910
See related
Ensembl:ENSG00000181036 MIM:613562; AllianceGenome:HGNC:31910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FcRH6
Summary
Enables MHC class II protein binding activity and protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 6.7), lung (RPKM 2.6) and 14 other tissues See more
Orthologs
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Genomic context

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Location:
1q23.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159800512..159816257)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158937524..158953270)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159770302..159786047)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:159751068-159751644 Neighboring gene dual specificity phosphatase 23 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9322 Neighboring gene Sharpr-MPRA regulatory region 9392 Neighboring gene uncharacterized LOC105371464 Neighboring gene SLAM family member 8 Neighboring gene small nucleolar RNA host gene 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159815652-159816152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159816153-159816653 Neighboring gene small nucleolar RNA SNORD64

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cutting edge: FcR-like 6 is an MHC class II receptor. Schreeder DM, et al. J Immunol, 2010 Jul 1. PMID 20519654, Free PMC Article
  2. FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia. Schreeder DM, et al. Eur J Immunol, 2008 Nov. PMID 18991291, Free PMC Article
  3. FCRL6 receptor: expression and associated proteins. Kulemzin SV, et al. Immunol Lett, 2011 Jan 30. PMID 20933011
  4. The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. Taylor AI, et al. Immunogenetics, 2007 Apr. PMID 17273841
  5. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Reiner AP, et al. Am J Hum Genet, 2012 Sep 7. PMID 22939635, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of Fc receptor-like 6 (FCRL6) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16056

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class II protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Fc receptor-like protein 6
Names
Fc receptor-like protein 7
IFGP6
IgSF type I transmembrane receptor
fc receptor homolog 6
fcR-like protein 6
leukocyte receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004310.3 → NP_001004310.2  Fc receptor-like protein 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004310.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).
    Source sequence(s)
    AI631310, AK131201, AL590560, AY513661, DA959587
    Consensus CDS
    CCDS30912.1
    UniProtKB/Swiss-Prot
    A1KXW6, A2A4D6, Q6DN72, Q6DN73, Q6XRC3, Q6ZNI1
    Related
    ENSP00000357086.3, ENST00000368106.4
    Conserved Domains (4) summary
    cd05753
    Location:19 → 98
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:123 → 198
    IG_like; Immunoglobulin like
    pfam13895
    Location:112 → 200
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:206 → 280
    Ig_3; Immunoglobulin domain

  2. NM_001284217.2 → NP_001271146.1  Fc receptor-like protein 6 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus.
    Source sequence(s)
    AI631310, AK131201
    Consensus CDS
    CCDS60312.1
    UniProtKB/Swiss-Prot
    Q6DN72
    Related
    ENSP00000320625.6, ENST00000321935.10
    Conserved Domains (4) summary
    cd05753
    Location:26 → 105
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:130 → 205
    IG_like; Immunoglobulin like
    pfam13895
    Location:119 → 207
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:213 → 287
    Ig_3; Immunoglobulin domain

  3. NM_001426231.1 → NP_001413160.1  Fc receptor-like protein 6 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL590560

  4. NM_001426232.1 → NP_001413161.1  Fc receptor-like protein 6 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL590560

  5. NM_001426233.1 → NP_001413162.1  Fc receptor-like protein 6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL590560

  6. NM_001426234.1 → NP_001413163.1  Fc receptor-like protein 6 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL590560

  7. NM_001426235.1 → NP_001413164.1  Fc receptor-like protein 6 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    CP068277

  8. NM_001426236.1 → NP_001413165.1  Fc receptor-like protein 6 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    CP068277

  9. NM_001426237.1 → NP_001413166.1  Fc receptor-like protein 6 isoform 9

    Status: VALIDATED

    Source sequence(s)
    CP068277

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159800512..159816257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245128.5 → XP_005245185.1  Fc receptor-like protein 6 isoform X1

    Conserved Domains (4) summary
    cd05753
    Location:29 → 108
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:133 → 208
    IG_like; Immunoglobulin like
    pfam13895
    Location:122 → 210
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:216 → 290
    Ig_3; Immunoglobulin domain

  2. XM_005245131.4 → XP_005245188.1  Fc receptor-like protein 6 isoform X4

    Related
    ENSP00000340949.5, ENST00000339348.9
    Conserved Domains (4) summary
    cd05753
    Location:29 → 108
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:133 → 208
    IG_like; Immunoglobulin like
    pfam13895
    Location:122 → 210
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:216 → 290
    Ig_3; Immunoglobulin domain

  3. XM_047419607.1 → XP_047275563.1  Fc receptor-like protein 6 isoform X6

  4. XM_011509480.3 → XP_011507782.1  Fc receptor-like protein 6 isoform X2

    Conserved Domains (4) summary
    cd05753
    Location:26 → 105
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:130 → 205
    IG_like; Immunoglobulin like
    pfam13895
    Location:119 → 207
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:213 → 287
    Ig_3; Immunoglobulin domain

  5. XM_047419606.1 → XP_047275562.1  Fc receptor-like protein 6 isoform X6

  6. XM_005245129.5 → XP_005245186.1  Fc receptor-like protein 6 isoform X3

    Conserved Domains (5) summary
    cd05753
    Location:14 → 93
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:118 → 193
    IG_like; Immunoglobulin like
    pfam11377
    Location:304 → 342
    DUF3180; Protein of unknown function (DUF3180)
    pfam13895
    Location:107 → 195
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:201 → 275
    Ig_3; Immunoglobulin domain

  7. XM_011509481.3 → XP_011507783.1  Fc receptor-like protein 6 isoform X5

    Conserved Domains (4) summary
    cd05753
    Location:29 → 108
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:133 → 208
    IG_like; Immunoglobulin like
    pfam13895
    Location:122 → 210
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:216 → 290
    Ig_3; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158937524..158953270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336355.1 → XP_054192330.1  Fc receptor-like protein 6 isoform X4

  2. XM_054336358.1 → XP_054192333.1  Fc receptor-like protein 6 isoform X10

  3. XM_054336353.1 → XP_054192328.1  Fc receptor-like protein 6 isoform X8

  4. XM_054336357.1 → XP_054192332.1  Fc receptor-like protein 6 isoform X10

  5. XM_054336354.1 → XP_054192329.1  Fc receptor-like protein 6 isoform X9

  6. XM_054336356.1 → XP_054192331.1  Fc receptor-like protein 6 isoform X5

  7. XM_054336352.1 → XP_054192327.1  Fc receptor-like protein 6 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DN72.2 GenPept UniProtKB/Swiss-Prot:Q6DN72

Gene LinkOut

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