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CRACDL CRACD like [ Homo sapiens (human) ]

Gene ID: 343990, updated on 5-Mar-2024

Summary

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Official Symbol
CRACDLprovided by HGNC
Official Full Name
CRACD likeprovided by HGNC
Primary source
HGNC:HGNC:33454
See related
Ensembl:ENSG00000196872 AllianceGenome:HGNC:33454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2orf55; KIAA1211L
Expression
Broad expression in brain (RPKM 4.1), esophagus (RPKM 1.2) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
2q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (98793846..98936225, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99252281..99394756, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99410309..99552688, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99386702-99387202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99387203-99387703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99389840-99390340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99390341-99390841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99391147-99392024 Neighboring gene long intergenic non-protein coding RNA 2611 Neighboring gene NANOG hESC enhancer GRCh37_chr2:99395023-99395587 Neighboring gene RNA, U4 small nuclear 84, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14605 Neighboring gene RNA, U7 small nuclear 46 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99485973-99486580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99526123-99526622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99529037-99529620 Neighboring gene Sharpr-MPRA regulatory region 6151 Neighboring gene MPRA-validated peak3796 silencer Neighboring gene testis specific 10 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:99656987-99658186 Neighboring gene NANOG hESC enhancer GRCh37_chr2:99698262-99699020 Neighboring gene SMC3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99758101-99758907 Neighboring gene chromosome 2 open reading frame 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent. Alblooshi H, et al. BMC Psychiatry, 2020 Jan 31. PMID 32005204, Free PMC Article
  2. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Scott LJ, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19416921, Free PMC Article
  3. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Kovalski JR, et al. Mol Cell, 2019 Feb 21. PMID 30639242, Free PMC Article
  4. The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei. Nassa G, et al. Sci Data, 2019 Sep 16. PMID 31527615, Free PMC Article
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Giurato G, et al. Sci Data, 2018 Mar 6. PMID 29509190, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.
    Title: Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC42367

General protein information

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Preferred Names
CRACD-like protein
Names
KIAA1211 like
uncharacterized protein C2orf55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207362.3 → NP_997245.2  CRACD-like protein

    See identical proteins and their annotated locations for NP_997245.2

    Status: VALIDATED

    Source sequence(s)
    AC084377, BC068277, BM922097, CF593294
    Consensus CDS
    CCDS42720.1
    UniProtKB/Swiss-Prot
    Q6NV74
    Related
    ENSP00000380996.2, ENST00000397899.7
    Conserved Domains (1) summary
    pfam15262
    Location:145 → 239
    DUF4592; Domain of unknown function (DUF4592)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    98793846..98936225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263926.4 → XP_005263983.1  CRACD-like protein isoform X4

    See identical proteins and their annotated locations for XP_005263983.1

    Conserved Domains (1) summary
    pfam15262
    Location:145 → 239
    DUF4592; Domain of unknown function (DUF4592)

  2. XM_017003972.2 → XP_016859461.1  CRACD-like protein isoform X3

    Conserved Domains (2) summary
    PRK07003
    Location:538 → 840
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15262
    Location:159 → 253
    DUF4592; Domain of unknown function (DUF4592)

  3. XM_011511094.2 → XP_011509396.1  CRACD-like protein isoform X4

    See identical proteins and their annotated locations for XP_011509396.1

    Conserved Domains (1) summary
    pfam15262
    Location:145 → 239
    DUF4592; Domain of unknown function (DUF4592)

  4. XM_011511093.2 → XP_011509395.1  CRACD-like protein isoform X3

    Conserved Domains (2) summary
    PRK07003
    Location:538 → 840
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15262
    Location:159 → 253
    DUF4592; Domain of unknown function (DUF4592)

  5. XM_017003971.2 → XP_016859460.1  CRACD-like protein isoform X3

    Conserved Domains (2) summary
    PRK07003
    Location:538 → 840
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15262
    Location:159 → 253
    DUF4592; Domain of unknown function (DUF4592)

  6. XM_011511095.2 → XP_011509397.1  CRACD-like protein isoform X4

    See identical proteins and their annotated locations for XP_011509397.1

    Conserved Domains (1) summary
    pfam15262
    Location:145 → 239
    DUF4592; Domain of unknown function (DUF4592)

  7. XM_005263924.4 → XP_005263981.1  CRACD-like protein isoform X2

    Conserved Domains (1) summary
    pfam15262
    Location:173 → 267
    DUF4592; Domain of unknown function (DUF4592)

  8. XM_005263923.4 → XP_005263980.1  CRACD-like protein isoform X1

    Conserved Domains (1) summary
    pfam15262
    Location:173 → 267
    DUF4592; Domain of unknown function (DUF4592)

  9. XM_011511096.1 → XP_011509398.1  CRACD-like protein isoform X5

    Conserved Domains (1) summary
    pfam15262
    Location:12 → 106
    DUF4592; Domain of unknown function (DUF4592)

  10. XM_047444123.1 → XP_047300079.1  CRACD-like protein isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    99252281..99394756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341737.1 → XP_054197712.1  CRACD-like protein isoform X4

  2. XM_054341733.1 → XP_054197708.1  CRACD-like protein isoform X3

  3. XM_054341736.1 → XP_054197711.1  CRACD-like protein isoform X4

  4. XM_054341734.1 → XP_054197709.1  CRACD-like protein isoform X3

  5. XM_054341735.1 → XP_054197710.1  CRACD-like protein isoform X3

  6. XM_054341738.1 → XP_054197713.1  CRACD-like protein isoform X4

  7. XM_054341732.1 → XP_054197707.1  CRACD-like protein isoform X2

  8. XM_054341731.1 → XP_054197706.1  CRACD-like protein isoform X1

  9. XM_054341739.1 → XP_054197714.1  CRACD-like protein isoform X5

  10. XM_054341740.1 → XP_054197715.1  CRACD-like protein isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NV74.3 GenPept UniProtKB/Swiss-Prot:Q6NV74

Gene LinkOut

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