Wdfy2 WD repeat and FYVE domain containing 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Wdfy2provided by FlyBase
Official Full Name: WD repeat and FYVE domain containing 2provided by FlyBase
Primary source: FLYBASE:FBgn0032246
Locus tag: Dmel_CG5168
See related: AllianceGenome:FB:FBgn0032246
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5168; Dmel\CG5168; WDFY2
Summary: Enables protein kinase binding activity. Located in endosome. Is expressed in adult head; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to several human genes including WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 31E1-31E1; 2-42 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10423291..10425482)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10423291..10425482)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat and FYVE domain containing 2

Names: CG5168-PA; CG5168-PB; Wdfy2-PA; Wdfy2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10423291..10425482

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201850.1 → NP_001188779.1 WD repeat and FYVE domain containing 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188779.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VKW1

Conserved Domains (4) summary

COG2319
Location:4 → 405

WD40; WD40 repeat [General function prediction only]

cd15718
Location:287 → 356

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:166 → 205

7WD40; WD40 repeat [structural motif]

cl02567
Location:24 → 279

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_135556.4 → NP_609400.1 WD repeat and FYVE domain containing 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609400.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VKW1

Related

FBpp0079610

Conserved Domains (4) summary

COG2319
Location:4 → 405

WD40; WD40 repeat [General function prediction only]

cd15718
Location:287 → 356

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:166 → 205

7WD40; WD40 repeat [structural motif]

cl02567
Location:24 → 279

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...