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CCT4 Chaperonin containing TCP1 subunit 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34674, updated on 10-May-2024

Summary

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Official Symbol
CCT4provided by FlyBase
Official Full Name
Chaperonin containing TCP1 subunit 4provided by FlyBase
Primary source
FLYBASE:FBgn0032444
Locus tag
Dmel_CG5525
See related
AllianceGenome:FB:FBgn0032444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cct4; Cct4; CG5525; Dmel\CG5525; Q9VK69_DROME; TCP-1; Tcp-1delta; Tcp1-delta; TCP1-delta
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; foregut primordium; germ layer; and gut section. Used to study intrinsic cardiomyopathy. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CCT4 in Genome Data Viewer
Location:
33F3-33F3; 2-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12690336..12692934, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12690336..12692934, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nubbin Neighboring gene RNA and export factor binding protein 2 Neighboring gene POU domain protein 2 Neighboring gene Neprilysin-like 7 Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 43 Neighboring gene Protein interacting with C kinase 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. Melkani GC, et al. FEBS Lett, 2017 Nov. PMID 28963798, Free PMC Article
  2. Drosophila melanogaster Sperm under Simulated Microgravity and a Hypomagnetic Field: Motility and Cell Respiration. Ogneva IV, et al. Int J Mol Sci, 2020 Aug 20. PMID 32825268, Free PMC Article
  3. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article
  4. Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Plimpton RL, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675501, Free PMC Article
  5. TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila. Kim AR, et al. Oncogene, 2019 Jun. PMID 30792539, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
chaperonin containing TCP1 subunit 4
Names
CCT4-PA
CG5525-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12690336..12692934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135735.3 → NP_609579.1  chaperonin containing TCP1 subunit 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609579.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK69
    Related
    FBpp0079992
    Conserved Domains (2) summary
    cd03338
    Location:18 → 531
    TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    pfam00118
    Location:37 → 529
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VK69 Q9VK69

Gene LinkOut

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