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APOE apolipoprotein E [ Homo sapiens (human) ]

Gene ID: 348, updated on 12-Sep-2021

Summary

Official Symbol
APOEprovided by HGNC
Official Full Name
apolipoprotein Eprovided by HGNC
Primary source
HGNC:HGNC:613
See related
Ensembl:ENSG00000130203 MIM:107741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD2; LPG; APO-E; ApoE4; LDLCQ5
Summary
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
Expression
Biased expression in liver (RPKM 1021.7), kidney (RPKM 648.1) and 7 other tissues See more
Orthologs
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Genomic context

See APOE in Genome Data Viewer
Location:
19q13.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44905796..44909393)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45409053..45412650)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 2 Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene APOC1 promoter region Neighboring gene apolipoprotein C1 Neighboring gene apolipoprotein C1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
GeneReviews: Not available
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
GeneReviews: Not available
A genome-wide scan for common variants affecting the rate of age-related cognitive decline.
GeneReviews: Not available
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
GeneReviews: Not available
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
GeneReviews: Not available
Age-related macular degeneration 1
MedGen: C1864205 OMIM: 603075 GeneReviews: Not available
Compare labs
Alzheimer disease 2
MedGen: C1863051 OMIM: 104310 GeneReviews: Not available
Compare labs
Alzheimer disease, type 3
MedGen: C1843013 OMIM: 607822 GeneReviews: Alzheimer Disease Overview
Compare labs
Alzheimer disease, type 4
MedGen: C1847200 OMIM: 606889 GeneReviews: Alzheimer Disease Overview
Compare labs
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
GeneReviews: Not available
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
GeneReviews: Not available
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
GeneReviews: Not available
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.
GeneReviews: Not available
Common variants at 30 loci contribute to polygenic dyslipidemia.
GeneReviews: Not available
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Examination of the current top candidate genes for AD in a genome-wide association study.
GeneReviews: Not available
Familial type 3 hyperlipoproteinemia
MedGen: C0020479 OMIM: 617347 GeneReviews: Not available
Compare labs
Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
GeneReviews: Not available
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
GeneReviews: Not available
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
GeneReviews: Not available
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available
Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.
GeneReviews: Not available
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
GeneReviews: Not available
Genome-wide analysis of genetic loci associated with Alzheimer disease.
GeneReviews: Not available
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
GeneReviews: Not available
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
GeneReviews: Not available
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
GeneReviews: Not available
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
GeneReviews: Not available
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
GeneReviews: Not available
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
GeneReviews: Not available
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
GeneReviews: Not available
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
GeneReviews: Not available
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
GeneReviews: Not available
Genome-wide association study of Alzheimer's disease.
GeneReviews: Not available
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
GeneReviews: Not available
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
GeneReviews: Not available
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
GeneReviews: Not available
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
GeneReviews: Not available
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
GeneReviews: Not available
High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.
GeneReviews: Not available
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
GeneReviews: Not available
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
GeneReviews: Not available
Lipoprotein glomerulopathy
MedGen: C2673196 OMIM: 611771 GeneReviews: Not available
Compare labs
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
GeneReviews: Not available
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
GeneReviews: Not available
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
GeneReviews: Not available
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
GeneReviews: Not available
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
GeneReviews: Not available
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
GeneReviews: Not available
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
GeneReviews: Not available
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
GeneReviews: Not available
Sea-blue histiocyte syndrome
MedGen: C0036489 OMIM: 269600 GeneReviews: Not available
Compare labs
Seven new loci associated with age-related macular degeneration.
GeneReviews: Not available
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
GeneReviews: Not available
Sorl1 as an Alzheimer's disease predisposition gene?
GeneReviews: Not available
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
GeneReviews: Not available
SUCLG2 identified as both a determinator of CSF Aß1-42-levels and an attenuator of cognitive decline in Alzheimer's disease.
GeneReviews: Not available
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes increased neurotoxicity in human neuronal cultures with the ApoE4 allele PubMed
Tat tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
tat The antioxidant properties of human lipidated apoE3 protects neurons from Tat-induced toxicity PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1571

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cholesterol transfer activity IEA
Inferred from Electronic Annotation
more info
 
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
enables low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables low-density lipoprotein particle receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables metal chelating activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylcholine-sterol O-acyltransferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
enables tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables very-low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables very-low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables very-low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect AMPA glutamate receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_positive_effect NMDA glutamate receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amyloid precursor protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cholesterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chylomicron remnant clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chylomicron remnant clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in high-density lipoprotein particle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in high-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in high-density lipoprotein particle remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intermediate-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular transport TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid transport involved in lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in low-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of location in cell IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cellular protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation by host of viral process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid fibril formation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cholesterol efflux IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cholesterol esterification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of dendritic spine maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heparan sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid transport across blood-brain barrier IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phospholipid efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of Cdc42 protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of amyloid fibril formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of amyloid precursor protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of amyloid-beta clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of amyloid-beta clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of axon extension TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to caloric restriction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
involved_in response to reactive oxygen species NAS
Non-traceable Author Statement
more info
PubMed 
involved_in reverse cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic transmission, cholinergic TAS
Traceable Author Statement
more info
PubMed 
involved_in triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in triglyceride metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride-rich lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
involved_in very-low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in very-low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very-low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in very-low-density lipoprotein particle remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in virion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in blood microparticle HDA PubMed 
part_of chylomicron IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite NAS
Non-traceable Author Statement
more info
PubMed 
part_of discoidal high-density lipoprotein particle TAS
Traceable Author Statement
more info
PubMed 
located_in early endosome TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular vesicle HDA PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of intermediate-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of intermediate-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in neuronal cell body NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 
part_of very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
apolipoprotein E
Names
apolipoprotein E3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007084.2 RefSeqGene

    Range
    5015..8612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000041.4NP_000032.1  apolipoprotein E isoform b precursor

    See identical proteins and their annotated locations for NP_000032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
    Source sequence(s)
    BC003557, HY056112
    Consensus CDS
    CCDS12647.1
    UniProtKB/Swiss-Prot
    P02649
    UniProtKB/TrEMBL
    A0A0S2Z3D5
    Related
    ENSP00000252486.3, ENST00000252486.9
    Conserved Domains (1) summary
    pfam01442
    Location:86266
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  2. NM_001302688.2NP_001289617.1  apolipoprotein E isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC003557, BM042032, HY056112
    UniProtKB/Swiss-Prot
    P02649
    Conserved Domains (1) summary
    pfam01442
    Location:112292
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  3. NM_001302689.2NP_001289618.1  apolipoprotein E isoform b precursor

    See identical proteins and their annotated locations for NP_001289618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
    Source sequence(s)
    BC003557, DB486513, HY074384
    Consensus CDS
    CCDS12647.1
    UniProtKB/Swiss-Prot
    P02649
    UniProtKB/TrEMBL
    A0A0S2Z3D5
    Conserved Domains (1) summary
    pfam01442
    Location:86266
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  4. NM_001302690.2NP_001289619.1  apolipoprotein E isoform b precursor

    See identical proteins and their annotated locations for NP_001289619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
    Source sequence(s)
    BC003557, CA771535, HY074888
    Consensus CDS
    CCDS12647.1
    UniProtKB/Swiss-Prot
    P02649
    UniProtKB/TrEMBL
    A0A0S2Z3D5
    Conserved Domains (1) summary
    pfam01442
    Location:86266
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  5. NM_001302691.2NP_001289620.1  apolipoprotein E isoform b precursor

    See identical proteins and their annotated locations for NP_001289620.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon and uses an alternate splice site in another 5' exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
    Source sequence(s)
    BC003557, BI550631
    Consensus CDS
    CCDS12647.1
    UniProtKB/Swiss-Prot
    P02649
    UniProtKB/TrEMBL
    A0A0S2Z3D5
    Conserved Domains (1) summary
    pfam01442
    Location:86266
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44905796..44909393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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