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Lamtor3 Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35055, updated on 10-May-2024

Summary

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Official Symbol
Lamtor3provided by FlyBase
Official Full Name
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3provided by FlyBase
Primary source
FLYBASE:FBgn0032642
Locus tag
Dmel_CG5110
See related
AllianceGenome:FB:FBgn0032642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE09173; CG5110; Dmel\CG5110; dMP1; MP1
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Part of Ragulator complex. Is expressed in several structures, including head and imaginal disc. Orthologous to human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Lamtor3 in Genome Data Viewer
Location:
36C10-36C10; 2-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17481231..17482037)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17481231..17482037)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene cassowary Neighboring gene four way stop Neighboring gene Glucosidase 2 beta subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of the MP1 scaffold protein in ERK signaling regulation during Drosophila wing development. Mouchel-Vielh E, et al. Genes Cells, 2008 Nov. PMID 18823331
  2. The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development. Mouchel-Vielh E, et al. BMC Dev Biol, 2011 Mar 14. PMID 21401930, Free PMC Article
  3. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. Koch R, et al. PLoS One, 2009. PMID 19234596, Free PMC Article
  4. Critical contribution of linker proteins to Raf kinase activation. Anselmo AN, et al. J Biol Chem, 2002 Feb 22. PMID 11741918
  5. Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation. Gelbart ME, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648925, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Corto, rl and dMP1 interact during wing tissue differentiation; Corto, ERK(rl) and dMP1 form a complex in the nucleus and co-localize on several sites on polytene chromosomes
    Title: The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.
  2. MEK Partner 1 (dMP1) functions in the control of cell differentiation during development of the Drosophila wing.
    Title: Involvement of the MP1 scaffold protein in ERK signaling regulation during Drosophila wing development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ragulator complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Ragulator complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Names
CG5110-PA
CG5110-PB
Lamtor3-PA
Lamtor3-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17481231..17482037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259133.2 → NP_001246062.1  late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246062.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VJD2
    UniProtKB/TrEMBL
    M9NEQ5
    Conserved Domains (1) summary
    pfam08923
    Location:3 → 121
    MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

  2. NM_135999.4 → NP_609843.1  late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VJD2
    UniProtKB/TrEMBL
    M9NEQ5
    Related
    FBpp0080536
    Conserved Domains (1) summary
    pfam08923
    Location:3 → 121
    MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NEQ5 M9NEQ5
Q9VJD2.1 Q9VJD2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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