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CG10376 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35126, updated on 10-May-2024

Summary

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Official Symbol
CG10376provided by FlyBase
Primary source
FLYBASE:FBgn0032702
Locus tag
Dmel_CG10376
See related
AllianceGenome:FB:FBgn0032702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10376; PP2C
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of protein kinase activity and protein dephosphorylation. Predicted to be located in cytoplasm and nucleus. Is expressed in lamina. Orthologous to several human genes including PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG10376 in Genome Data Viewer
Location:
37A1-37A1; 2-54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18700606..18703105, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18700606..18703105, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Jwa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phosphoswitch at acinus-serine(437) controls autophagic responses to cadmium exposure and neurodegenerative stress. Nandi N, et al. Elife, 2022 Jan 17. PMID 35037620, Free PMC Article
  2. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
  3. Microarray analysis of immune challenged Drosophila hemocytes. Johansson KC, et al. Exp Cell Res, 2005 Apr 15. PMID 15777795
  4. The Hippo pathway promotes cell survival in response to chemical stress. Di Cara F, et al. Cell Death Differ, 2015 Sep. PMID 26021298, Free PMC Article
  5. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Horn T, et al. Nat Methods, 2011 Apr. PMID 21378980

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10376-PA
NP_609899.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18700606..18703105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136055.3 → NP_609899.1  uncharacterized protein Dmel_CG10376 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609899.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ61
    Related
    FBpp0080672
    Conserved Domains (1) summary
    cd00143
    Location:160 → 419
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ61 Q9VJ61

Gene LinkOut

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