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JCHAIN joining chain of multimeric IgA and IgM [ Homo sapiens (human) ]

Gene ID: 3512, updated on 3-Apr-2024

Summary

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Official Symbol
JCHAINprovided by HGNC
Official Full Name
joining chain of multimeric IgA and IgMprovided by HGNC
Primary source
HGNC:HGNC:5713
See related
Ensembl:ENSG00000132465 MIM:147790; AllianceGenome:HGNC:5713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGJ; JCH; IGCJ
Summary
Enables IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to other organism; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues See more
Orthologs
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Genomic context

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See JCHAIN in Genome Data Viewer
Location:
4q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70655541..70666508, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73998009..74019368, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71521258..71532225, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71464845-71465050 Neighboring gene ameloblastin Neighboring gene enamelin Neighboring gene uncharacterized LOC101927297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71553174-71554144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71554145-71555113 Neighboring gene UTP3 small subunit processome component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression and glycoengineering of functionally active heteromultimeric IgM in plants. Loos A, et al. Proc Natl Acad Sci U S A, 2014 Apr 29. PMID 24706782, Free PMC Article
  2. Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly. Atkin JD, et al. J Immunol, 1996 Jul 1. PMID 8683109
  3. The J chain gene is transcribed during B and T lymphopoiesis in humans. Bertrand FE 3rd, et al. J Immunol, 1996 Jun 1. PMID 8666793
  4. Glandular distribution of immunoglobulins, J chain, secretory component, and HLA-DR in the human endometrium throughout the menstrual cycle. Bjercke S, et al. Hum Reprod, 1993 Sep. PMID 8253928
  5. Expression of J chain mRNA in duodenal IgA plasma cells in IgA nephropathy. Harper SJ, et al. Kidney Int, 1994 Mar. PMID 8196286

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF-kappaB signaling pathway.
    Title: IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF‑κB signaling pathway.
  2. Results show that ID1, ID3 and IGJ genes are highly expressed in adult B-ALL and correlate with poor prognosis in Hispanic patients.
    Title: High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.
  3. TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells.
    Title: Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables antigen binding NAS
Non-traceable Author Statement
more info
 PubMed 
contributes_to immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to immunoglobulin receptor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of respiratory burst IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
part_of dimeric IgA immunoglobulin complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
NOT part_of hexameric IgM immunoglobulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of monomeric IgA immunoglobulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pentameric IgM immunoglobulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pentameric IgM immunoglobulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of secretory IgA immunoglobulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of secretory dimeric IgA immunoglobulin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
immunoglobulin J chain
Names
IgJ chain
J chain
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144646.4 → NP_653247.1  immunoglobulin J chain precursor

    See identical proteins and their annotated locations for NP_653247.1

    Status: VALIDATED

    Source sequence(s)
    BC038982, BP221304, BP418109
    Consensus CDS
    CCDS3545.1
    UniProtKB/Swiss-Prot
    P01591
    UniProtKB/TrEMBL
    D6RD17
    Related
    ENSP00000254801.4, ENST00000254801.9
    Conserved Domains (1) summary
    pfam15097
    Location:24 → 159
    Ig_J_chain; Immunoglobulin J chain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    70655541..70666508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    73998009..74019368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349954.1 → XP_054205929.1  immunoglobulin J chain isoform X2

    UniProtKB/Swiss-Prot
    P01591

  2. XM_054349955.1 → XP_054205930.1  immunoglobulin J chain isoform X2

    UniProtKB/Swiss-Prot
    P01591

  3. XM_054349953.1 → XP_054205928.1  immunoglobulin J chain isoform X2

    UniProtKB/Swiss-Prot
    P01591

  4. XM_054349952.1 → XP_054205927.1  immunoglobulin J chain isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01591.4 GenPept UniProtKB/Swiss-Prot:P01591

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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