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EMC5 ER membrane protein complex subunit 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35159, updated on 11-Apr-2024

Summary

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Official Symbol
EMC5provided by FlyBase
Official Full Name
ER membrane protein complex subunit 5provided by FlyBase
Primary source
FLYBASE:FBgn0032732
Locus tag
Dmel_CG15168
See related
AllianceGenome:FB:FBgn0032732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE09053; CG15168; Dmel\CG15168; emc5
Summary
Predicted to enable inorganic cation transmembrane transporter activity. Predicted to be part of EMC complex. Predicted to be active in Golgi apparatus; early endosome; and plasma membrane. Is expressed in adult head; adult heart; and organism. Orthologous to human MMGT1 (membrane magnesium transporter 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EMC5 in Genome Data Viewer
Location:
37B8-37B8; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18987707..18988331)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18987707..18988331)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transport and Golgi organization 6 Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized protein Neighboring gene Swiprosin-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
  2. Application of Fluorescent Proteins for Functional Dissection of the Drosophila Visual System. Smylla TK, et al. Int J Mol Sci, 2021 Aug 19. PMID 34445636, Free PMC Article
  3. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
  4. Genome-wide RNAi screen identifies networks involved in intestinal stem cell regulation in Drosophila. Zeng X, et al. Cell Rep, 2015 Feb 24. PMID 25704823, Free PMC Article
  5. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables inorganic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tail-anchored membrane protein insertion into ER membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ER membrane protein complex subunit 5
Names
CG15168-PA
EMC5-PA
endoplasmic reticulum membrane protein complex 5
subunit 5 of EMC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18987707..18988331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136082.4 → NP_609926.1  ER membrane protein complex subunit 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609926.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ25
    Related
    FBpp0080679
    Conserved Domains (1) summary
    pfam10270
    Location:32 → 62
    MMgT; Membrane magnesium transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ25 Q9VJ25

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