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phr6-4 (6-4)-photolyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35322, updated on 4-Apr-2024

Summary

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Official Symbol
phr6-4provided by FlyBase
Official Full Name
(6-4)-photolyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0016054
Locus tag
Dmel_CG2488
See related
AllianceGenome:FB:FBgn0016054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38D.25; 6-4 PHR; 64-PL; 64PHR; CG2488; D6-4; Dm 64; Dmel\CG2488; phr(6-4)
Summary
Predicted to enable DNA binding activity; FAD binding activity; and deoxyribodipyrimidine photo-lyase activity. Predicted to be involved in circadian regulation of gene expression and entrainment of circadian clock by photoperiod. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; endoderm; and gonad. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1) and CRY2 (cryptochrome circadian regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See phr6-4 in Genome Data Viewer
Location:
38D2-38D2; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20643351..20645791, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20643351..20645791, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Seminal fluid protein 38D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene U snoRNA host gene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The three-dimensional structure of Drosophila melanogaster (6-4) photolyase at room temperature. Cellini A, et al. Acta Crystallogr D Struct Biol, 2021 Aug 1. PMID 34342273, Free PMC Article
  2. Electron Transfer-Induced Active Site Structural Relaxation in 64-Photolyase of Drosophila melanogaster. Osswald M, et al. J Phys Chem B, 2021 Aug 12. PMID 34323497
  3. Crystal structure of the T(6-4)C lesion in complex with a (6-4) DNA photolyase and repair of UV-induced (6-4) and Dewar photolesions. Glas AF, et al. Chemistry, 2009 Oct 12. PMID 19722240
  4. Crystal structure and mechanism of a DNA (6-4) photolyase. Maul MJ, et al. Angew Chem Int Ed Engl, 2008. PMID 18956392
  5. Non-mutagenic repair of (6-4)photoproducts by (6-4)photolyase purified from Drosophila melanogaster. Todo T, et al. Mutat Res, 1997 Nov. PMID 9447230

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Electron Transfer-Induced Active Site Structural Relaxation in 64-Photolyase of Drosophila melanogaster.
    Title: Electron Transfer-Induced Active Site Structural Relaxation in 64-Photolyase of Drosophila melanogaster.
  2. The first crystal structures of a (6-4) photolyase was described.
    Title: Crystal structure and mechanism of a DNA (6-4) photolyase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribodipyrimidine photo-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribodipyrimidine photo-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
(6-4)-photolyase
Names
(6-4) photolyase
(6-4)photolyase
6-4 photolyase
64-photolyase
CG2488-PA
CG2488-PB
CG2488-PC
CG2488-PD
photolyase
phr6-4-PA
phr6-4-PB
phr6-4-PC
phr6-4-PD
NP_001260632.1
NP_001260633.1
NP_477188.1
NP_724274.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20643351..20645791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165334.3 → NP_724274.1  (6-4)-photolyase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724274.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8P0, Q8SXK5
    Related
    FBpp0080934
    Conserved Domains (2) summary
    COG0415
    Location:5 → 499
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:297 → 496
    FAD_binding_7; FAD binding domain of DNA photolyase

  2. NM_057840.5 → NP_477188.1  (6-4)-photolyase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8P0, Q8SXK5
    Related
    FBpp0080935
    Conserved Domains (2) summary
    COG0415
    Location:5 → 499
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:297 → 496
    FAD_binding_7; FAD binding domain of DNA photolyase

  3. NM_001273704.1 → NP_001260633.1  (6-4)-photolyase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260633.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8P0, Q8SXK5
    Conserved Domains (2) summary
    COG0415
    Location:5 → 499
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:297 → 496
    FAD_binding_7; FAD binding domain of DNA photolyase

  4. NM_001273703.1 → NP_001260632.1  (6-4)-photolyase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8P0, Q8SXK5
    Conserved Domains (2) summary
    COG0415
    Location:5 → 499
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:297 → 496
    FAD_binding_7; FAD binding domain of DNA photolyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E8P0 Q0E8P0
Q24281 Q24281
Q8SXK5 Q8SXK5

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