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Tbx3 T-box transcription factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 353305, updated on 30-Sep-2021

Summary

Official Symbol
Tbx3provided by RGD
Official Full Name
T-box transcription factor 3provided by RGD
Primary source
RGD:735203
See related
EnsemblRapid:ENSRNOG00000008706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
human homolog acts as a transcriptional repressor and plays a role in the development of several organ systems [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 379.4), Lung (RPKM 114.2) and 5 other tissues See more
Orthologs
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Genomic context

See Tbx3 in Genome Data Viewer
Location:
12q16
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (36879924..36894849, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (42479518..42494588, complement)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 5 Neighboring gene uncharacterized LOC102549962 Neighboring gene uncharacterized LOC102551526 Neighboring gene uncharacterized LOC120095983

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in anterior/posterior axis specification, embryo ISO
Inferred from Sequence Orthology
more info
 
involved_in anterior/posterior axis specification, embryo ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within atrioventricular bundle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular canal development ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular canal morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac chamber development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac jelly development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell aging ISO
Inferred from Sequence Orthology
more info
 
involved_in cell aging ISO
Inferred from Sequence Orthology
more info
 
involved_in cell aging ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digit morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic forelimb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in female genitalia development ISO
Inferred from Sequence Orthology
more info
 
involved_in female genitalia development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in follicle-stimulating hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in heart looping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within limbic system development ISO
Inferred from Sequence Orthology
more info
 
involved_in luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in luteinizing hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in male genitalia development ISO
Inferred from Sequence Orthology
more info
 
involved_in male genitalia development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within mammary placode formation ISO
Inferred from Sequence Orthology
more info
 
involved_in mesoderm morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mesoderm morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell proliferation involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sinoatrial node cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in sinoatrial node cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within specification of animal organ position ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ureteric peristalsis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-box transcription factor TBX3
Names
T-box 3 (ulnar mammary syndrome)
T-box protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181638.1NP_853669.1  T-box transcription factor TBX3

    See identical proteins and their annotated locations for NP_853669.1

    Status: PROVISIONAL

    Source sequence(s)
    AY289619
    UniProtKB/Swiss-Prot
    Q7TST9
    Related
    ENSRNOP00000011552.2, ENSRNOT00000011552.5
    Conserved Domains (2) summary
    pfam12598
    Location:323404
    TBX; T-box transcription factor
    cd20188
    Location:101305
    T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    36879924..36894849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089539.1XP_038945467.1  T-box transcription factor TBX3 isoform X1

    Conserved Domains (2) summary
    pfam12598
    Location:323404
    TBX; T-box transcription factor
    cd20188
    Location:101305
    T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins
  2. XM_006249416.4XP_006249478.1  T-box transcription factor TBX3 isoform X1

    See identical proteins and their annotated locations for XP_006249478.1

    UniProtKB/Swiss-Prot
    Q7TST9
    Conserved Domains (2) summary
    pfam12598
    Location:323404
    TBX; T-box transcription factor
    cd20188
    Location:101305
    T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins
  3. XM_006249417.4XP_006249479.1  T-box transcription factor TBX3 isoform X1

    See identical proteins and their annotated locations for XP_006249479.1

    UniProtKB/Swiss-Prot
    Q7TST9
    Conserved Domains (2) summary
    pfam12598
    Location:323404
    TBX; T-box transcription factor
    cd20188
    Location:101305
    T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins
  4. XM_006249418.2XP_006249480.1  T-box transcription factor TBX3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8D7
    Related
    ENSRNOP00000074567.1, ENSRNOT00000084018.2
    Conserved Domains (2) summary
    pfam12598
    Location:303393
    TBX; T-box transcription factor
    cd00182
    Location:102287
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
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