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CG9331 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35347, updated on 10-May-2024

Summary

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Official Symbol
CG9331provided by FlyBase
Primary source
FLYBASE:FBgn0032889
Locus tag
Dmel_CG9331
See related
AllianceGenome:FB:FBgn0032889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG9331; GRHPR
Summary
Predicted to enable glycerate dehydrogenase activity; glyoxylate reductase (NADP+) activity; and hydroxypyruvate reductase activity. Located in extracellular region. Is expressed in several structures, including adult head; adult heart; embryonic epidermis; embryonic/larval midgut; and yolk nucleus. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG9331 in Genome Data Viewer
Location:
38F1-38F1; 2-54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20822828..20827744)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20822828..20827744)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Chemosensory protein B 38a Neighboring gene Chemosensory protein B 38c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Outer segment 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic reprogramming of chromatin accessibility during Drosophila embryo development. Thomas S, et al. Genome Biol, 2011. PMID 21569360, Free PMC Article
  2. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. Emtenani S, et al. EMBO J, 2022 Jun 14. PMID 35319107, Free PMC Article
  3. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Jha AR, et al. Mol Biol Evol, 2016 Feb. PMID 26576852, Free PMC Article
  4. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Chen CL, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26362788, Free PMC Article
  5. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxypyruvate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG9331-PA
CG9331-PB
CG9331-PC
CG9331-PD
CG9331-PF
CG9331-PG
CG9331-PH
CG9331-PI
CG9331-PJ
CG9331-PK
CG9331-PL
CG9331-PM
NP_001188857.1
NP_001188858.1
NP_001188859.1
NP_001188860.1
NP_001286107.1
NP_001286108.1
NP_001286109.1
NP_610062.2
NP_724293.2
NP_788080.1
NP_788081.1
NP_995737.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20822828..20827744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299179.1 → NP_001286108.1  uncharacterized protein Dmel_CG9331, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q7KT11, Q7KT12
    Conserved Domains (2) summary
    COG1052
    Location:8 → 320
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 318
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  2. NM_001299178.1 → NP_001286107.1  uncharacterized protein Dmel_CG9331, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q8SZU0
    Conserved Domains (2) summary
    COG1052
    Location:46 → 358
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:46 → 356
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  3. NM_176066.4 → NP_788080.1  uncharacterized protein Dmel_CG9331, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788080.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q8SZU0
    Related
    FBpp0080949
    Conserved Domains (2) summary
    COG1052
    Location:46 → 358
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:46 → 356
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  4. NM_001201928.2 → NP_001188857.1  uncharacterized protein Dmel_CG9331, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q7KT11, Q7KT12
    Conserved Domains (2) summary
    COG1052
    Location:8 → 320
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 318
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  5. NM_001201931.2 → NP_001188860.1  uncharacterized protein Dmel_CG9331, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q8SZU0
    Conserved Domains (2) summary
    COG1052
    Location:46 → 358
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:46 → 356
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  6. NM_206015.3 → NP_995737.2  uncharacterized protein Dmel_CG9331, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995737.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q7KT11, Q7KT12
    Conserved Domains (2) summary
    COG1052
    Location:8 → 320
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 318
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  7. NM_001201930.2 → NP_001188859.1  uncharacterized protein Dmel_CG9331, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188859.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q8SZU0
    Conserved Domains (2) summary
    COG1052
    Location:46 → 358
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:46 → 356
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  8. NM_001201929.2 → NP_001188858.1  uncharacterized protein Dmel_CG9331, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188858.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q7KT11, Q7KT12
    Conserved Domains (2) summary
    COG1052
    Location:8 → 320
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 318
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  9. NM_176067.3 → NP_788081.1  uncharacterized protein Dmel_CG9331, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788081.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q7KT11, Q7KT12
    Related
    FBpp0080948
    Conserved Domains (2) summary
    COG1052
    Location:8 → 320
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 318
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  10. NM_136218.4 → NP_610062.2  uncharacterized protein Dmel_CG9331, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610062.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q7KT11, Q7KT12
    Related
    FBpp0080946
    Conserved Domains (2) summary
    COG1052
    Location:8 → 320
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8 → 318
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  11. NM_001299180.1 → NP_001286109.1  uncharacterized protein Dmel_CG9331, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286109.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q9VIJ0
    Conserved Domains (2) summary
    COG1052
    Location:46 → 358
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:46 → 356
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

  12. NM_165345.3 → NP_724293.2  uncharacterized protein Dmel_CG9331, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724293.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP73, Q9VIJ0
    Related
    FBpp0080947
    Conserved Domains (2) summary
    COG1052
    Location:46 → 358
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:46 → 356
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KT11 Q7KT11
Q8SZU0 Q8SZU0
Q9VIJ0 Q9VIJ0

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