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Pld3 Phospholipase D family member 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35384, updated on 4-Apr-2024

Summary

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Official Symbol
Pld3provided by FlyBase
Official Full Name
Phospholipase D family member 3provided by FlyBase
Primary source
FLYBASE:FBgn0032923
Locus tag
Dmel_CG9248
See related
AllianceGenome:FB:FBgn0032923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9248; Dmel\CG9248; dPLD3
Summary
Predicted to enable single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in regulation of cytokine production involved in inflammatory response. Predicted to be located in endoplasmic reticulum membrane and lysosomal lumen. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to several human genes including PLD3 (phospholipase D family member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Pld3 in Genome Data Viewer
Location:
39A6-39A7; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21158847..21160903)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21158847..21160903)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 2 Neighboring gene M-phase phosphoprotein 6 Neighboring gene Coenzyme Q3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. V232M substitution restricts a distinct O-glycosylation of PLD3 and its neuroprotective function. Demirev AV, et al. Neurobiol Dis, 2019 Sep. PMID 31121321
  2. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu P, et al. Development, 2001 Dec. PMID 11748144
  3. Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. Hansen KD, et al. PLoS Genet, 2009 Jun. PMID 19543372, Free PMC Article
  4. Genetic Dissection of Alzheimer's Disease Using Drosophila Models. Jeon Y, et al. Int J Mol Sci, 2020 Jan 30. PMID 32019113, Free PMC Article
  5. Transcriptional response to alcohol exposure in Drosophila melanogaster. Morozova TV, et al. Genome Biol, 2006. PMID 17054780, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal lumen ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phospholipase D family member 3
Names
CG9248-PA
CG9248-PB
CG9248-PC
Pld3-PA
Pld3-PB
Pld3-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21158847..21160903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136249.2 → NP_610093.1  phospholipase D family member 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIF2
    Related
    FBpp0080999
    Conserved Domains (3) summary
    PHA03003
    Location:84 → 493
    PHA03003; palmytilated EEV membrane glycoprotein; Provisional
    cd09106
    Location:89 → 249
    PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
    cd09107
    Location:316 → 486
    PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins

  2. NM_001299188.1 → NP_001286117.1  phospholipase D family member 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286117.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIF2
    Conserved Domains (3) summary
    PHA03003
    Location:84 → 493
    PHA03003; palmytilated EEV membrane glycoprotein; Provisional
    cd09106
    Location:89 → 249
    PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
    cd09107
    Location:316 → 486
    PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins

  3. NM_165356.3 → NP_724313.1  phospholipase D family member 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724313.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIF2
    Related
    FBpp0081000
    Conserved Domains (3) summary
    PHA03003
    Location:84 → 493
    PHA03003; palmytilated EEV membrane glycoprotein; Provisional
    cd09106
    Location:89 → 249
    PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
    cd09107
    Location:316 → 486
    PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIF2 Q9VIF2

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