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CG43345 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35387, updated on 27-Mar-2024

Summary

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Official Symbol
CG43345provided by FlyBase
Primary source
FLYBASE:FBgn0263050
Locus tag
Dmel_CG43345
See related
AllianceGenome:FB:FBgn0263050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9243; Dmel\CG43345
Old locus tag
Dmel_CG9243
Summary
Predicted to enable single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome. Is expressed in organism. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to several human genes including PLD3 (phospholipase D family member 3) and PLD4 (phospholipase D family member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CG43345 in Genome Data Viewer
Location:
39A7-39A7; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21166046..21168581, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21166046..21168581, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1 Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene burgundy

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A misexpression screen to identify regulators of Drosophila larval hemocyte development. Stofanko M, et al. Genetics, 2008 Sep. PMID 18757933, Free PMC Article
  2. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article
  3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  4. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208
  5. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG43345-PB
CG43345-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21166046..21168581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042907.2 → NP_001036372.2  uncharacterized protein Dmel_CG43345, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036372.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960R3, Q9VIE9
    Conserved Domains (3) summary
    PHA03003
    Location:87 → 488
    PHA03003; palmytilated EEV membrane glycoprotein; Provisional
    cd09106
    Location:98 → 247
    PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
    cd09107
    Location:300 → 479
    PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins

  2. NM_136252.4 → NP_610096.1  uncharacterized protein Dmel_CG43345, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610096.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960R3, Q9VIE9
    Related
    FBpp0297826
    Conserved Domains (3) summary
    PHA03003
    Location:87 → 488
    PHA03003; palmytilated EEV membrane glycoprotein; Provisional
    cd09106
    Location:98 → 247
    PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
    cd09107
    Location:300 → 479
    PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIE9 Q9VIE9

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