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Mcm10 Minichromosome maintenance 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35390, updated on 4-Apr-2024

Summary

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Official Symbol
Mcm10provided by FlyBase
Official Full Name
Minichromosome maintenance 10provided by FlyBase
Primary source
FLYBASE:FBgn0032929
Locus tag
Dmel_CG9241
See related
AllianceGenome:FB:FBgn0032929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9241; dMcm10; Dmel\CG9241; DmMCM10; mcm10; MCM10; Scim19
Summary
Predicted to enable DNA replication origin binding activity and single-stranded DNA binding activity. Involved in several processes, including DNA endoreduplication; negative regulation of compound eye retinal cell apoptotic process; and positive regulation of R7 cell differentiation. Located in nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
39B1-39B1; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21179933..21182812)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21179933..21182812)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene burgundy Neighboring gene antisense RNA:CR44911 Neighboring gene Ret oncogene Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mcm10 is required for oogenesis and early embryogenesis in Drosophila. Reubens MC, et al. Mech Dev, 2015 Nov. PMID 26369283, Free PMC Article
  2. Drosophila Mcm10 is required for DNA replication and differentiation in the compound eye. Vo N, et al. PLoS One, 2014. PMID 24686397, Free PMC Article
  3. Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mapping. Gallone G, et al. BMC Bioinformatics, 2011 Jul 18. PMID 21767381, Free PMC Article
  4. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
  5. Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles. Apger J, et al. Genetics, 2010 Aug. PMID 20498296, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of both HP1a and Mcm10 genes inhibited the progression of S phase in eye imaginal discs. Proximity Ligation Assay (PLA) demonstrated that HP1a is in close proximity to DNA replication proteins including Mcm10, RFC140 and DNA polymerase epsilon 255 kDa subunit in S-phase.
    Title: Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation.
  2. Observation of embryonic nuclear morphology and quantification of embryo hatch rates reveal that maternal loading of Mcm10 is required for embryonic nuclear stability, and suggest a role for Mcm10 post zygotic transition.
    Title: Mcm10 is required for oogenesis and early embryogenesis in Drosophila.
  3. Data show that Mcm10 has a role in heterochromatic silencing and chromosome condensation.
    Title: Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye-antennal disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of compound eye retinal cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of R7 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
minichromosome maintenance 10
Names
CG9241-PA
Mcm10-PA
sensitized chromosome inheritance modifier 19

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21179933..21182812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136253.4 → NP_610097.2  minichromosome maintenance 10 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610097.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RC7, Q9VIE6
    UniProtKB/TrEMBL
    A9UNF9
    Related
    FBpp0081004
    Conserved Domains (2) summary
    pfam09329
    Location:323 → 367
    zf-primase; Primase zinc finger
    pfam09332
    Location:468 → 756
    Mcm10; Mcm10 replication factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIE6.2 Q9VIE6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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