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EcR Ecdysone receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35540, updated on 20-Aug-2019

Summary

Official Symbol
EcRprovided by FlyBase
Official Full Name
Ecdysone receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0000546
Locus tag
Dmel_CG1765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0229075.1; CG1765; CG8347; dECR; DEcR; Dhr23; dmEcR; DmEcR; Dmel\CG1765; EcdR; ecr; Ecr; ECR; EcR-A; EcR-B; EcR-B1; ECR-C; Ecr1B; EcR1b; EcRA; EcRB; EcRB-1; EcrB1; EcRB1; EcRC; lie; ms(2)06410; ms(2)42A; NR1H1; snt; Usp; USP

Genomic context

See EcR in Genome Data Viewer
Location:
42A9-42A12; 2-55 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6087873..6169087, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1975378..2056592, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 5 Neighboring gene Arsenic resistance protein 2 Neighboring gene transfer RNA:Arginine-ACG 1-1 Neighboring gene transfer RNA:Lysine-CTT 1-1 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Asparagine-GTT 1-1 Neighboring gene transfer RNA:Asparagine-GTT 1-2 Neighboring gene transfer RNA:Asparagine-GTT 1-3 Neighboring gene long non-coding RNA:CR43904 Neighboring gene transfer RNA:Arginine-ACG 1-2 Neighboring gene transfer RNA:Asparagine-GTT 1-4 Neighboring gene transfer RNA:Asparagine-GTT 1-5 Neighboring gene transfer RNA:Asparagine-GTT 1-6 Neighboring gene transfer RNA:Lysine-CTT 1-2 Neighboring gene transfer RNA:Lysine-CTT 1-3 Neighboring gene transfer RNA:Lysine-CTT 1-4 Neighboring gene transfer RNA:Isoleucine-AAT 1-1 Neighboring gene transfer RNA:Arginine-ACG 1-3 Neighboring gene transfer RNA:Lysine-CTT 1-5

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

mobile_element

  • Loc: c6159410-6159321 mobile_element_type = transposon:INE-1{}6230
  • Loc: c6160802-6160638 mobile_element_type = transposon:INE-1{}6232
  • Loc: c6164596-6163223 mobile_element_type = transposon:Tc1-2{}1730
  • Loc: c6164830-6164800 mobile_element_type = transposon:1360{}1727
  • Loc: c6166506-6166405 mobile_element_type = transposon:INE-1{}6239

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IPI
Inferred from Physical Interaction
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
ecdysone binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to nuclear receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid binding NAS
Non-traceable Author Statement
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardioblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal vessel heart proper cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ecdysone receptor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ecdysone-mediated induction of salivary gland cell autophagic cell death NAS
Non-traceable Author Statement
more info
PubMed 
epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ-band shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
head involution IMP
Inferred from Mutant Phenotype
more info
PubMed 
histoblast morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc-derived wing morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
larval central nervous system remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
larval central nervous system remodeling TAS
Traceable Author Statement
more info
PubMed 
larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
larval wandering behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
metamorphosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mushroom body development IGI
Inferred from Genetic Interaction
more info
PubMed 
mushroom body development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis NAS
Non-traceable Author Statement
more info
PubMed 
peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
pupariation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Malpighian tubule diameter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of development, heterochronic TAS
Traceable Author Statement
more info
PubMed 
regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of rhodopsin gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to ecdysone IMP
Inferred from Mutant Phenotype
more info
PubMed 
salivary gland cell autophagic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
sperm individualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activator ecdysone receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
ecdysone receptor holocomplex IPI
Inferred from Physical Interaction
more info
PubMed 
ecdysone receptor holocomplex TAS
Traceable Author Statement
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 
polytene chromosome NAS
Non-traceable Author Statement
more info
PubMed 
repressor ecdysone receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
ecdysone receptor
Names
CG1765-PA
CG1765-PB
CG1765-PC
CG1765-PD
CG1765-PE
CG1765-PG
EcR-PA
EcR-PB
EcR-PC
EcR-PD
EcR-PE
EcR-PG
Ecdysone-R
ecdyson receptor 1b
ecdysone receptor complex
ecdysone-Receptor
ecdysteroid receptor
ecdysterone receptor
long island expressway
male sterile(2)42A
snaggletooth

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6087873..6169087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169590.2NP_001163061.1  ecdysone receptor, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34021
    UniProtKB/TrEMBL
    E1JGY2
    Related
    FBpp0291631, FBtr0302439
    Conserved Domains (2) summary
    cd06938
    Location:420652
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:261351
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
  2. NM_165461.3NP_724456.1  ecdysone receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724456.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34021
    UniProtKB/TrEMBL
    A4UZ51
    Related
    FBpp0085349, FBtr0086008
    Conserved Domains (2) summary
    cd06938
    Location:391623
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:232322
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
  3. NM_165463.2NP_724458.1  ecdysone receptor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724458.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34021
    UniProtKB/TrEMBL
    A4UZ51
    Related
    FBpp0085351, FBtr0086010
    Conserved Domains (2) summary
    cd06938
    Location:391623
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:232322
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
  4. NM_165464.3NP_724459.1  ecdysone receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34021
    Related
    FBpp0085353, FBtr0086012
    Conserved Domains (2) summary
    cd06938
    Location:211443
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:52142
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
  5. NM_165462.2NP_724457.1  ecdysone receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724457.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34021
    UniProtKB/TrEMBL
    A4UZ51
    Related
    FBpp0085350, FBtr0086009
    Conserved Domains (2) summary
    cd06938
    Location:391623
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:232322
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
  6. NM_165465.3NP_724460.1  ecdysone receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34021
    UniProtKB/TrEMBL
    E1JGY2
    Related
    FBpp0085352, FBtr0086011
    Conserved Domains (2) summary
    cd06938
    Location:420652
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:261351
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
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