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IL1RAP interleukin 1 receptor accessory protein [ Homo sapiens (human) ]

Gene ID: 3556, updated on 11-Apr-2024

Summary

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Official Symbol
IL1RAPprovided by HGNC
Official Full Name
interleukin 1 receptor accessory proteinprovided by HGNC
Primary source
HGNC:HGNC:5995
See related
Ensembl:ENSG00000196083 MIM:602626; AllianceGenome:HGNC:5995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL1R3; C3orf13; IL-1RAcP
Summary
This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]
Expression
Broad expression in liver (RPKM 11.2), placenta (RPKM 7.8) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3q28
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (190514085..190659750)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (193330399..193476092)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190231874..190377539)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15001 Neighboring gene claudin 16 Neighboring gene claudin 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:190080003-190080564 Neighboring gene Sharpr-MPRA regulatory region 3521 Neighboring gene Sharpr-MPRA regulatory region 14389 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:190158638-190158813 Neighboring gene transmembrane protein 207 Neighboring gene Sharpr-MPRA regulatory region 15127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:190232063-190232564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:190232565-190233064 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:190258615-190259497 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:190283646-190284845 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:190302729-190303262 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:190303263-190303796 Neighboring gene NANOG hESC enhancer GRCh37_chr3:190363652-190364224 Neighboring gene glucosaminyl (N-acetyl) transferase 1 pseudogene 3 Neighboring gene RN7SK pseudogene 296 Neighboring gene long intergenic non-protein coding RNA 2013 Neighboring gene chaperonin containing TCP1 subunit 6 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models. Ågerstam H, et al. Haematologica, 2023 Feb 1. PMID 36226493, Free PMC Article
  2. IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma. Badi YE, et al. Allergy, 2023 Jan. PMID 35986608, Free PMC Article
  3. Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia. Trad R, et al. J Immunother Cancer, 2022 Jul. PMID 35803613, Free PMC Article
  4. Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer. Zhang Y, et al. J Hematol Oncol, 2022 May 23. PMID 35606824, Free PMC Article
  5. Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma. Zhang HF, et al. Cancer Discov, 2021 Nov. PMID 34021002, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies.
    Title: Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies.
  2. Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.
    Title: Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.
  3. CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis.
    Title: CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis.
  4. IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models.
    Title: IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models.
  5. IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma.
    Title: IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma.
  6. Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia.
    Title: Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia.
  7. Novel IL1RAP mutation associated with schizophrenia interferes with neuronal growth and related NF-kappaB signal pathways.
    Title: Novel IL1RAP mutation associated with schizophrenia interferes with neuronal growth and related NF-κB signal pathways.
  8. Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
    Title: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
  9. Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma.
    Title: Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma.
  10. The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma.
    Title: The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
EBI GWAS Catalog
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-33 receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-33-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in trans-synaptic signaling by trans-synaptic complex IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-1 receptor accessory protein
Names
IL-1 receptor accessory protein
interleukin-1 receptor 3
interleukin-1 receptor accessory protein beta
NP_001161400.1
NP_001161401.1
NP_001161402.1
NP_001161403.1
NP_001351808.1
NP_001351809.1
NP_001351810.1
NP_002173.1
NP_608273.1
XP_016861837.1
XP_047304037.1
XP_047304038.1
XP_047304039.1
XP_047304040.1
XP_047304041.1
XP_047304042.1
XP_054202423.1
XP_054202424.1
XP_054202425.1
XP_054202426.1
XP_054202427.1
XP_054202428.1
XP_054202429.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029105.2 RefSeqGene

    Range
    5035..142464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167928.2 → NP_001161400.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001161400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. It encodes the membrane-bound isoform (1).
    Source sequence(s)
    AB006537, AK291669, BG032519, BM194193, BM760155, BM973472
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3
    UniProtKB/TrEMBL
    A8K6K4
    Related
    ENSP00000401132.1, ENST00000439062.6
    Conserved Domains (3) summary
    pfam01582
    Location:405 → 546
    TIR; TIR domain
    pfam13927
    Location:242 → 335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

  2. NM_001167929.2 → NP_001161401.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001161401.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes the membrane-bound isoform (1).
    Source sequence(s)
    AF538733, BM194193, BM973472, DA024801
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3
    UniProtKB/TrEMBL
    A8K6K4
    Related
    ENSP00000072516.3, ENST00000072516.7
    Conserved Domains (3) summary
    pfam01582
    Location:405 → 546
    TIR; TIR domain
    pfam13927
    Location:242 → 335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

  3. NM_001167930.2 → NP_001161402.1  interleukin-1 receptor accessory protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. It encodes the soluble isoform (2).
    Source sequence(s)
    AC008249, AF538732, DA024801
    Consensus CDS
    CCDS46982.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000387371.1, ENST00000422940.5
    Conserved Domains (2) summary
    pfam13927
    Location:242 → 335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

  4. NM_001167931.2 → NP_001161403.1  interleukin-1 receptor accessory protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001161403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC108747, DA024801, DN990628, EF591790
    Consensus CDS
    CCDS54696.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000314807.3, ENST00000317757.8
    Conserved Domains (4) summary
    smart00255
    Location:404 → 547
    TIR; Toll - interleukin 1 - resistance
    cd20931
    Location:243 → 349
    Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)
    cd20992
    Location:25 → 132
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cd20993
    Location:143 → 235
    Ig2_IL-1RAP_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

  5. NM_001364879.1 → NP_001351808.1  interleukin-1 receptor accessory protein isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008249, AC108747
    Consensus CDS
    CCDS54696.1
    Conserved Domains (4) summary
    smart00255
    Location:404 → 547
    TIR; Toll - interleukin 1 - resistance
    cd20931
    Location:243 → 349
    Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)
    cd20992
    Location:25 → 132
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cd20993
    Location:143 → 235
    Ig2_IL-1RAP_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

  6. NM_001364880.2 → NP_001351809.1  interleukin-1 receptor accessory protein isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008249, AC108747
    Conserved Domains (2) summary
    pfam13927
    Location:242 → 335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

  7. NM_001364881.2 → NP_001351810.1  interleukin-1 receptor accessory protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008249, AC108747
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3
    UniProtKB/TrEMBL
    A8K6K4
    Conserved Domains (3) summary
    pfam01582
    Location:405 → 546
    TIR; TIR domain
    pfam13927
    Location:242 → 335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

  8. NM_002182.4 → NP_002173.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_002173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the membrane-bound isoform (1).
    Source sequence(s)
    AB006537, BM194193, BM973472, DA024801
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3
    UniProtKB/TrEMBL
    A8K6K4
    Related
    ENSP00000390541.1, ENST00000447382.6
    Conserved Domains (3) summary
    pfam01582
    Location:405 → 546
    TIR; TIR domain
    pfam13927
    Location:242 → 335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

  9. NM_134470.4 → NP_608273.1  interleukin-1 receptor accessory protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_608273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' end of the coding region and 3' UTR, compared to variant 1. It encodes the soluble isoform (2).
    Source sequence(s)
    AC008249, AF538734, BC053621, DA024801
    Consensus CDS
    CCDS46982.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000409352.1, ENST00000422485.5
    Conserved Domains (2) summary
    pfam13927
    Location:242 → 335
    Ig_3; Immunoglobulin domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

RNA

  1. NR_157352.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC108747, AF538730, BM973472, HY121126
    Related
    ENST00000413869.5

  2. NR_157353.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC108747, AF538731, BM973472, HY121126
    Related
    ENST00000342550.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    190514085..190659750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448081.1 → XP_047304037.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  2. XM_047448084.1 → XP_047304040.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  3. XM_047448082.1 → XP_047304038.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  4. XM_047448083.1 → XP_047304039.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  5. XM_047448085.1 → XP_047304041.1  interleukin-1 receptor accessory protein isoform X2

  6. XM_047448086.1 → XP_047304042.1  interleukin-1 receptor accessory protein isoform X4

  7. XM_017006348.3 → XP_016861837.1  interleukin-1 receptor accessory protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    193330399..193476092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346448.1 → XP_054202423.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  2. XM_054346451.1 → XP_054202426.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  3. XM_054346449.1 → XP_054202424.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  4. XM_054346450.1 → XP_054202425.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    B1NLD0, D3DNW0, O14915, Q86WJ7, Q9NPH3

  5. XM_054346452.1 → XP_054202427.1  interleukin-1 receptor accessory protein isoform X2

  6. XM_054346454.1 → XP_054202429.1  interleukin-1 receptor accessory protein isoform X4

  7. XM_054346453.1 → XP_054202428.1  interleukin-1 receptor accessory protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPH3.2 GenPept UniProtKB/Swiss-Prot:Q9NPH3

Gene LinkOut

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