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Glo1 Glyoxalase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35656, updated on 10-May-2024

Summary

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Official Symbol
Glo1provided by FlyBase
Official Full Name
Glyoxalase 1provided by FlyBase
Primary source
FLYBASE:FBgn0283450
Locus tag
Dmel_CG1707
See related
AllianceGenome:FB:FBgn0283450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1707; Dmel\CG1707; glo1
Summary
Enables lactoylglutathione lyase activity. Involved in regulation of insulin receptor signaling pathway. Is expressed in adult head and organism. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Glo1 in Genome Data Viewer
Location:
43B2-43B2; 2-56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7393546..7395932, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3281051..3283437, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene costa Neighboring gene DEAH-box helicase 15 Neighboring gene Gustatory receptor 43a Neighboring gene antisense RNA:CR44201 Neighboring gene ELL-associated factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Vicente Miranda H, et al. Brain, 2017 May 1. PMID 28398476
  2. Loxl2 is a mediator of cardiac aging in Drosophila melanogaster, genetically examining the role of aging clock genes. Bouska MJ, et al. G3 (Bethesda), 2022 Jan 4. PMID 34734976, Free PMC Article
  3. Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Moraru A, et al. Cell Metab, 2018 Apr 3. PMID 29551588
  4. Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. Pfaff DH, et al. J Biol Chem, 2017 Jan 13. PMID 27903648, Free PMC Article
  5. Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity. Garrido D, et al. PLoS Genet, 2015 Feb. PMID 25692475, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lactoylglutathione lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lactoylglutathione lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lactoylglutathione lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
glyoxalase 1
Names
CG1707-PA
Glo1-PA
NP_610270.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7393546..7395932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136426.3 → NP_610270.1  glyoxalase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6X6
    Related
    FBpp0088085
    Conserved Domains (1) summary
    cl14632
    Location:15 → 173
    Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z6X6 A1Z6X6
Q8MYU8 Q8MYU8

Gene LinkOut

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