ptc patched [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ptcprovided by FlyBase
Official Full Name: patchedprovided by FlyBase
Primary source: FLYBASE:FBgn0003892
Locus tag: Dmel_CG2411
See related: AllianceGenome:FB:FBgn0003892
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH36596; CG2411; com4; Conf; Dmel\CG2411; dPtc; l(2)k02507; pat; Patched; Ptc; PTC; ptch; Ptch; Ptc_Dm; rubr; tuf
Summary: Enables several functions, including hedgehog family protein binding activity; hedgehog receptor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in several processes, including Bolwig's organ morphogenesis; imaginal disc development; and regulation of signal transduction. Located in basal plasma membrane; cilium; and endocytic vesicle. Is integral component of plasma membrane. Colocalizes with fusome. Is expressed in several structures, including anterior-posterior subdivision of organism; eye-antennal disc; gonad; gut section; and presumptive embryonic/larval system. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1) and PTCH2 (patched 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 44D5-44E1; 2-59 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8649649..8665223)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4537154..4552728)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development.
Title: Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development.
Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc.
Title: Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc.
SHH-Patched signal transduction is instrumental for development in Drosophila and for tumor cells communication in humans.
Title: Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding.
Patched and Ihog activity are mutually required for receptor endocytosis and degradation, triggered by Hedgehog protein binding, and causing reduced levels of Ihog/Boi proteins in a stripe of cells at the anterior/posterior compartment boundary of the wing imaginal disc.
Title: Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs.
a mutation of the PTC PY motif, which mediates binding of C2-WW-HECT family members, inhibits its internalization but not its autonomous and non-autonomous signalling activities. the two related UB-C2-WW-HECT ligases NEDD4 and SU(DX) regulate PTC trafficking and finely tune its accumulation through partially redundant but distinct functions
Title: Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases.
Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression.
Title: The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.
in vivo study demonstrates that the PI3K-cIII complex is essential for downregulating Patched via the endosomal-lysosomal pathway to execute axon pruning
Title: The PI3K class III complex promotes axon pruning by downregulating a Ptc-derived signal via endosome-lysosomal degradation.
Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand
Title: Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.
Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient.
Title: Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient.
lipophorins internalization does not play a major role in Hedgehog (Hh) signal transduction but does in Hh gradient formation
Title: Patched, the receptor of Hedgehog, is a lipoprotein receptor.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hedgehog family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables hedgehog family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables hedgehog family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables hedgehog receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables hedgehog receptor activity	IEA Inferred from Electronic Annotation more info
enables hedgehog receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipoprotein particle receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables smoothened binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Bolwig's organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior lineage restriction, imaginal disc	TAS Traceable Author Statement more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with fusome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: patched

Names: CG2411-PA; compaction defects 4; confused; patch; ptc-PA; rubberneck; tufted

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8649649..8665223

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078937.4 → NP_523661.2 patched [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523661.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P18502, Q9V4W3

Related

FBpp0088443

Conserved Domains (2) summary

TIGR00918
Location:17 → 1134

2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family

cl21543
Location:454 → 598

MMPL; MMPL family