IL10RA interleukin 10 receptor subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL10RAprovided by HGNC
Official Full Name: interleukin 10 receptor subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:5964
See related: Ensembl:ENSG00000110324 MIM:146933; AllianceGenome:HGNC:5964
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
Summary: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Expression: Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (117986394..118003037)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (118002773..118019416)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (117857109..117873752)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
Title: Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
Title: IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.
Title: Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.
Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
Title: Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
IL-10 suppresses IFN-gamma-mediated signaling in lung adenocarcinoma.
Title: IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
[Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].
Title: [Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].
Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
Title: Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10.
Title: Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10.
Two SNPs, rs3024490 and rs1800871, were found to be significantly different between breast cancer patients and healthy women. These SNPs also increased the risk of breast cancer in co-dominant and dominant models. Another SNP, rs1554286, was significantly associated with an increased risk of breast cancer in the co-dominant model.
Title: The effect of interleukin 10 polymorphisms on breast cancer susceptibility in Han women in Shaanxi Province.

Submit: New GeneRIF Correction See all GeneRIFs (81)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Inflammatory bowel disease 28 MedGen: C2751053 OMIM: 613148 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G15965 (e-PCR)
- UniSTS:15682

RH17971 (e-PCR)
- UniSTS:49486

WI-7357 (e-PCR)
- UniSTS:54476

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables interleukin-10 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-10 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-10 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal epithelial structure maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-10 receptor subunit alpha

Names: IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10RA; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; interleukin-10 receptor subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016275.1 RefSeqGene

Range

5001..20093

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GenBank, FASTA, Sequence Viewer (Graphics), LRG_151

mRNA and Protein(s)

NM_001558.4 → NP_001549.2 interleukin-10 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_001549.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the protein-coding transcript.

Source sequence(s)

AK291645, AP002962, BC028082, CA307153

Consensus CDS

CCDS8388.1

UniProtKB/Swiss-Prot

A8K6I0, B0YJ27, Q13651

UniProtKB/TrEMBL

H2DF05

Related

ENSP00000227752.4, ENST00000227752.8

Conserved Domains (2) summary

pfam01108
Location:21 → 111

Tissue_fac; Tissue factor

cl21522
Location:129 → 227

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

NR_026691.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate exon compared to variant 1. It is not thought to be protein-coding.

Source sequence(s)

AK291645, AK301484, AP002962, BC028082, CA307153

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

117986394..118003037

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426882.1 → XP_047282838.1 interleukin-10 receptor subunit alpha isoform X1
XM_047426884.1 → XP_047282840.1 interleukin-10 receptor subunit alpha isoform X3
XM_047426883.1 → XP_047282839.1 interleukin-10 receptor subunit alpha isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

118002773..118019416

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054368667.1 → XP_054224642.1 interleukin-10 receptor subunit alpha isoform X1
XM_054368669.1 → XP_054224644.1 interleukin-10 receptor subunit alpha isoform X3
XM_054368668.1 → XP_054224643.1 interleukin-10 receptor subunit alpha isoform X2