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IL11 interleukin 11 [ Homo sapiens (human) ]

Gene ID: 3589, updated on 17-Mar-2024

Summary

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Official Symbol
IL11provided by HGNC
Official Full Name
interleukin 11provided by HGNC
Primary source
HGNC:HGNC:5966
See related
Ensembl:ENSG00000095752 MIM:147681; AllianceGenome:HGNC:5966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGIF; IL-11
Summary
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Expression
Biased expression in endometrium (RPKM 2.0), appendix (RPKM 1.5) and 8 other tissues See more
Orthologs
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Genomic context

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See IL11 in Genome Data Viewer
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55364382..55370463, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58459867..58465950, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55875750..55881831, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11025 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55871113-55871613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55874435-55875039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55880086-55880927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55881771-55882611 Neighboring gene CRISPRi-validated cis-regulatory element chr19.6204 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:55885919-55886140 Neighboring gene transmembrane protein 190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55890663-55891163 Neighboring gene transmembrane protein 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55895260-55896222

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Interleukin-11 in Pathologies of the Nervous System]. Airapetov MI, et al. Mol Biol (Mosk), 2023 Jan-Feb. PMID 36976735
  2. The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis. Stuart SF, et al. Int J Mol Sci, 2023 Feb 8. PMID 36834778, Free PMC Article
  3. Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer. Leung JH, et al. Cells, 2022 Jul 21. PMID 35883698, Free PMC Article
  4. Mutational Analysis of Interleukin-11 and its Consequences on Cancer and COVID-19 Related Cytokine Storm -An Extensive Molecular Dynamics Study. Ray S, et al. Protein Pept Lett, 2022. PMID 35382714
  5. IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy. Wu P, et al. Front Endocrinol (Lausanne), 2022. PMID 35273577, Free PMC Article

See all (203) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
    Title: Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
  2. IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFbeta.
    Title: IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
  3. Understanding interleukin 11 as a disease gene and therapeutic target.
    Title: Understanding interleukin 11 as a disease gene and therapeutic target.
  4. m[6]A modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.
    Title: m(6)A modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.
  5. Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Ralpha/glycoprotein 130 signaling complex.
    Title: Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex.
  6. Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11.
    Title: Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11.
  7. Elevated interleukin-11 in systemic sclerosis and role in disease pathogenesis.
    Title: Elevated interleukin-11 in systemic sclerosis and role in disease pathogenesis.
  8. IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.
    Title: IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.
  9. [Interleukin-11 in Pathologies of the Nervous System].
    Title: [Interleukin-11 in Pathologies of the Nervous System].
  10. IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury.
    Title: IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury.
Submit: New GeneRIF Correction See all GeneRIFs (179)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells PubMed
Tat tat HIV-1 Tat upregulates the expression of interleukin 11 gene (IL11) in mammary epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-11 receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in fat cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in interleukin-11-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in megakaryocyte differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
NOT involved_in negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in regulation of complement-dependent cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-11
Names
adipogenesis inhibitory factor
oprelvekin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000641.4 → NP_000632.1  interleukin-11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC020922, AK315294, BF055151
    Consensus CDS
    CCDS12923.1
    UniProtKB/Swiss-Prot
    B4DQV5, P20809, Q96EB4
    UniProtKB/TrEMBL
    A8K3F7
    Related
    ENSP00000264563.1, ENST00000264563.7
    Conserved Domains (1) summary
    pfam07400
    Location:23 → 199
    IL11; Interleukin 11

  2. NM_001267718.2 → NP_001254647.1  interleukin-11 isoform 2

    See identical proteins and their annotated locations for NP_001254647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC020922, AK298973, BF055151
    Consensus CDS
    CCDS59423.1
    UniProtKB/Swiss-Prot
    P20809
    Related
    ENSP00000465705.1, ENST00000590625.5
    Conserved Domains (1) summary
    pfam07400
    Location:1 → 120
    IL11; Interleukin 11

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55364382..55370463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58459867..58465950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20809.1 GenPept UniProtKB/Swiss-Prot:P20809

Gene LinkOut

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