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Prosalpha7 Proteasome alpha7 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36018, updated on 4-Apr-2024

Summary

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Official Symbol
Prosalpha7provided by FlyBase
Official Full Name
Proteasome alpha7 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0023175
Locus tag
Dmel_CG1519
See related
AllianceGenome:FB:FBgn0023175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1519; alpha-7; Alpha-7; alpha7; Alpha7; alpha7_dm; CG1519; CPalpha7; Dmel\CG1519; Pros alpha7; prosalpha7; PROSalpha7; PSA3_DROME
Summary
Involved in ovarian follicle cell development and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head; adult heart; and organism. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
46B4-46B4; 2-61 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9846636..9847836, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5734141..5735341, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Mitochondrial amidoxime reducing component Neighboring gene Vesicle-associated membrane protein 7 Neighboring gene sting Neighboring gene Origin recognition complex subunit 6 Neighboring gene uncharacterized protein Neighboring gene Pyruvate carboxylase Neighboring gene antisense RNA:CR44293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway. Chinen M, et al. Biochem Biophys Res Commun, 2017 Feb 12. PMID 28087276, Free PMC Article
  2. Isolation of natural products with anti-ageing activity from the fruits of Platanus orientalis. Chatzigeorgiou S, et al. Phytomedicine, 2017 Sep 15. PMID 28887920
  3. PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, et al. Dev Cell, 2019 Aug 19. PMID 31327739, Free PMC Article
  4. Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster. Tsakiri EN, et al. Free Radic Biol Med, 2013 Dec. PMID 23999505
  5. Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. Lipinszki Z, et al. FEBS J, 2011 Dec. PMID 21973017

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proteasome alpha7 subunit
Names
20S proteasome subunit alpha 7
20S proteasome subunit alpha-7
20s proteasome
CG1519-PA
Prosalpha7-PA
alpha-subunit of 20S proteasome
alpha7
proteasome subunit alpha type-3
proteosome alpha7 subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9846636..9847836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165703.3 → NP_724834.1  proteasome alpha7 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17313, Q8MKU6, Q9V5C6
    Related
    FBpp0089041
    Conserved Domains (2) summary
    COG0638
    Location:6 → 231
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03751
    Location:5 → 216
    proteasome_alpha_type_3; proteasome_alpha_type_3. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V5C6.1 Q9V5C6

Gene LinkOut

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