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Crisp2 cysteine-rich secretory protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360445, updated on 29-Feb-2024

Summary

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Official Symbol
Crisp2provided by RGD
Official Full Name
cysteine-rich secretory protein 2provided by RGD
Primary source
RGD:621653
See related
Ensembl:ENSRNOG00000013225 AllianceGenome:RGD:621653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tpx1; Crisp2l
Summary
Involved in cell-cell adhesion. Predicted to be active in extracellular space. Orthologous to human CRISP2 (cysteine rich secretory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 5113.6) See more
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Genomic context

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Location:
9q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (27604024..27628520)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (20107649..20131967)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (23503223..23527502)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily ac, polypeptide 1 Neighboring gene Rh-associated glycoprotein Neighboring gene exocrine gland-secreted peptide 1-like Neighboring gene ribosomal protein L36A, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of the rat Tpx-1 responsible for the interaction between spermatogenic and Sertoli cells. Maeda T, et al. Biochem Biophys Res Commun, 1998 Jul 9. PMID 9675100
  2. Identification of a rat testis-specific gene encoding a potential rat outer dense fibre protein. O'Bryan MK, et al. Mol Reprod Dev, 1998 Jul. PMID 9621307
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cysteine-rich secretory protein 2
Names
testis specific protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011710.2 → NP_001011710.1  cysteine-rich secretory protein 2 precursor

    See identical proteins and their annotated locations for NP_001011710.1

    Status: VALIDATED

    Source sequence(s)
    BC078799, CK469282
    UniProtKB/TrEMBL
    A6JJ62, F7FBM2, O88205, Q9R1L4
    Related
    ENSRNOP00000017996.4, ENSRNOT00000017996.7
    Conserved Domains (2) summary
    cd05383
    Location:36 → 172
    CAP_CRISP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins
    pfam08562
    Location:189 → 243
    Crisp

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    27604024..27628520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244643.5 → XP_006244705.1  cysteine-rich secretory protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006244705.1

    UniProtKB/TrEMBL
    A6JJ62, F7FBM2, O88205, Q9R1L4
    Conserved Domains (2) summary
    cd05383
    Location:36 → 172
    CAP_CRISP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins
    pfam08562
    Location:189 → 243
    Crisp

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031240.1: Suppressed sequence

    Description
    NM_031240.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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