sel seele [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: selprovided by FlyBase
Official Full Name: seeleprovided by FlyBase
Primary source: FLYBASE:FBgn0263260
Locus tag: Dmel_CG12918
See related: AllianceGenome:FB:FBgn0263260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12918; CNPYa; Dmel\CG12918; Sle
Summary: Predicted to enable chaperone binding activity. Involved in polarity specification of dorsal/ventral axis; regulation of protein processing; and regulation of protein secretion. Located in endoplasmic reticulum. Is expressed in several structures, including circulatory system; embryonic dorsal epidermis; embryonic/larval fat body; gut section; and head mesoderm derivative. Used to study prostate cancer. Orthologous to several human genes including CNPY2 (canopy FGF signaling regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10050862..10052167, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5938367..5939672, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Seele has a role in the trafficking of Easter to the perivitelline space.
Title: Localization and activation of the Drosophila protease easter require the ER-resident saposin-like protein seele.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	HMP more info	PubMed
involved_in polarity specification of dorsal/ventral axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain