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Rufy1 RUN and FYVE domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360521, updated on 13-Apr-2024

Summary

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Official Symbol
Rufy1provided by RGD
Official Full Name
RUN and FYVE domain containing 1provided by RGD
Primary source
RGD:1305099
See related
Ensembl:ENSRNOG00000003536 AllianceGenome:RGD:1305099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and identical protein binding activity. Predicted to be involved in protein transport and regulation of endocytosis. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be located in cytosol; endosome; and nuclear speck. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human RUFY1 (RUN and FYVE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 134.4), Heart (RPKM 123.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35206801..35251696, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34705741..34750644, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35882805..35927268, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene chibby family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene uncharacterized LOC103693320 Neighboring gene uncharacterized LOC120095319

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. Yang J, et al. J Biol Chem, 2002 Aug 16. PMID 11877430
  2. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Cormont M, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11172003, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
NOT located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RUN and FYVE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100727.1 → NP_001094197.1  RUN and FYVE domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HE22, F1LR42
    Related
    ENSRNOP00000004740.5, ENSRNOT00000004740.6
    Conserved Domains (3) summary
    cd15758
    Location:637 → 707
    FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
    pfam02759
    Location:150 → 273
    RUN; RUN domain
    cl02073
    Location:443 → 588
    DUF3422; Protein of unknown function (DUF3422)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    35206801..35251696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086301.2 → XP_038942229.1  RUN and FYVE domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    TIGR02168
    Location:284 → 540
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15758
    Location:545 → 615
    FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
    pfam02759
    Location:58 → 179
    RUN; RUN domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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