Myh4 myosin heavy chain 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh4provided by RGD
Official Full Name: myosin heavy chain 4provided by RGD
Primary source: RGD:3139
See related: Ensembl:ENSRNOG00000049695 AllianceGenome:RGD:3139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable double-stranded RNA binding activity. Involved in several processes, including response to gravity; response to muscle activity; and response to muscle stretch. Predicted to be located in myofibril. Predicted to be part of myosin complex. Biomarker of sciatic neuropathy. Orthologous to human MYH4 (myosin heavy chain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 80591.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (52422148..52445296)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (51923149..51946297)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (53778456..53801605)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise training showed a myosin heavy chain shift from type IIb to IIa skeletal muscles.
Title: Different adaptations of alpha-actinin isoforms to exercise training in rat skeletal muscles.
although the sarcomeric stability of paralyzed muscle might be impaired, moderate mechanical loading does not seem to affect paralyzed muscle protein composition
Title: Botulinum toxin-induced paralysis leads to slower myosin heavy chain isoform composition and reduced titin content in juvenile rat gastrocnemius muscle.
myosin IIB has a key role in promoting accumulation of mutant Ca(v)2.1Ct at the plasma membrane
Title: Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myh1 (e-PCR), detects polymorphism
- UniSTS:143949

UniSTS:265579 (e-PCR)
- UniSTS:265579

Myh4 (e-PCR), detects polymorphism
- UniSTS:265579

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle structure development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle stretch	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-4

Names: 2B myosin heavy chain; myHC-2b; myosin heavy chain 2b; myosin heavy chain type IIb; myosin, heavy chain 4, skeletal muscle; myosin, heavy polypeptide 4, skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019325.1 → NP_062198.1 myosin-4

See identical proteins and their annotated locations for NP_062198.1

Status: PROVISIONAL

Source sequence(s)

BC113948

UniProtKB/Swiss-Prot

Q29RW1

UniProtKB/TrEMBL

F1LMU0

Related

ENSRNOP00000046362.3, ENSRNOT00000045718.5

Conserved Domains (8) summary

cd14915
Location:100 → 770

MYSc_Myh4; class II myosin heavy chain 4, motor domain

pfam00063
Location:88 → 770

Myosin_head; Myosin head (motor domain)

pfam01576
Location:850 → 1927

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 73

Myosin_N; Myosin N-terminal SH3-like domain

cl00459
Location:1299 → 1411

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl19219
Location:1506 → 1582

DUF342; Protein of unknown function (DUF342)

cl19764
Location:1376 → 1511

COG6; Conserved oligomeric complex COG6

cl23720
Location:994 → 1098

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)