Naglu N-acetyl-alpha-glucosaminidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nagluprovided by RGD
Official Full Name: N-acetyl-alpha-glucosaminidaseprovided by RGD
Primary source: RGD:1564228
See related: Ensembl:ENSRNOG00000032381 AllianceGenome:RGD:1564228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564228
Summary: Predicted to enable hydrolase activity. Predicted to act upstream of or within several processes, including cerebellar Purkinje cell layer development; locomotor rhythm; and sensory organ development. Predicted to be located in extracellular exosome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V; mucopolysaccharidosis III; and mucopolysaccharidosis type IIIB. Orthologous to human NAGLU (N-acetyl-alpha-glucosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 108.2), Lung (RPKM 65.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86501864..86509333)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86001545..86009049)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88979363..88986879)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urinary KIM-1, NGAL and NAG were compared against serum creatinine and renal histological score in the initiation, maintenance, and recovery phases of cisplatin (CP)-induced acute kidney injury.
Title: Urinary tubular protein-based biomarkers in the rodent model of cisplatin nephrotoxicity: a comparative analysis of serum creatinine, renal histology, and urinary KIM-1, NGAL, and NAG in the initiation, maintenance, and recovery phases of acute kidney injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142272 (e-PCR)
- UniSTS:231519

RH134495 (e-PCR)
- UniSTS:217775

RH143446 (e-PCR)
- UniSTS:232693

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-N-acetylglucosaminidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amyloid precursor protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular lipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar Purkinje cell layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collagen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cone retinal bipolar cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasm organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ganglioside metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycosaminoglycan metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart valve development	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heparan sulfate proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heparin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotor rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microglia differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microglial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroinflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to disaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal rod cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rod bipolar cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sequestering of iron ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within superoxide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vacuole organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle tethering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal lumen	ISO Inferred from Sequence Orthology more info
is_active_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-N-acetylglucosaminidase

Names: N-acetylglucosaminidase, alpha

NP_001413972.1

EC 3.2.1.50

XP_038943670.1

EC 3.2.1.50

XP_038943673.1

EC 3.2.1.50

XP_063125505.1

EC 3.2.1.50

XP_063125507.1

EC 3.2.1.50

XP_063125508.1

EC 3.2.1.50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427043.1 → NP_001413972.1 alpha-N-acetylglucosaminidase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HJ73, D3ZZL3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86501864..86509333

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087742.2 → XP_038943670.1 alpha-N-acetylglucosaminidase isoform X2

UniProtKB/TrEMBL

A6HJ76

Conserved Domains (2) summary

pfam05089
Location:1 → 309

NAGLU; Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain

pfam12972
Location:318 → 572

NAGLU_C; Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
XM_063269435.1 → XP_063125505.1 alpha-N-acetylglucosaminidase isoform X1
XM_063269437.1 → XP_063125507.1 alpha-N-acetylglucosaminidase isoform X3
XM_039087745.2 → XP_038943673.1 alpha-N-acetylglucosaminidase isoform X4

Conserved Domains (2) summary

pfam05089
Location:6 → 189

NAGLU; Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain

pfam12972
Location:198 → 452

NAGLU_C; Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
XM_063269438.1 → XP_063125508.1 alpha-N-acetylglucosaminidase isoform X5