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C11h21orf91 similar to human chromosome 21 open reading frame 91 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360692, updated on 3-Apr-2024

Summary

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Official Symbol
C11h21orf91provided by RGD
Official Full Name
similar to human chromosome 21 open reading frame 91provided by RGD
Primary source
RGD:1563888
See related
AllianceGenome:RGD:1563888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563888
Summary
Predicted to be involved in cerebral cortex neuron differentiation and positive regulation of dendritic spine development. Orthologous to human C21orf91 (chromosome 21 open reading frame 91). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 93.4), Thymus (RPKM 87.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (30716034..30749292, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (17229129..17262307, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (17073296..17120235, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene BTG anti-proliferation factor 3 Neighboring gene uncharacterized LOC120095596 Neighboring gene uncharacterized LOC120095597 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 31 Neighboring gene chondrolectin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome. Li SS, et al. Sci Rep, 2016 Jul 11. PMID 27404227, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cerebral cortex neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein EURL homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108312.4 → NP_001101782.1  protein EURL homolog

    See identical proteins and their annotated locations for NP_001101782.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6JL42
    Conserved Domains (1) summary
    pfam06937
    Location:1 → 283
    EURL; EURL protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    30716034..30749292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088457.2 → XP_038944385.1  protein EURL homolog isoform X2

    Conserved Domains (1) summary
    pfam06937
    Location:14 → 253
    EURL; EURL protein

  2. XM_017598023.3 → XP_017453512.1  protein EURL homolog isoform X1

    UniProtKB/TrEMBL
    A6JL42
    Conserved Domains (1) summary
    pfam06937
    Location:1 → 283
    EURL; EURL protein

  3. XM_008768531.4 → XP_008766753.1  protein EURL homolog isoform X1

    See identical proteins and their annotated locations for XP_008766753.1

    UniProtKB/TrEMBL
    A6JL42
    Conserved Domains (1) summary
    pfam06937
    Location:1 → 283
    EURL; EURL protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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