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Rufy3 RUN and FYVE domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360921, updated on 30-Sep-2021

Summary

Official Symbol
Rufy3provided by RGD
Official Full Name
RUN and FYVE domain containing 3provided by RGD
Primary source
RGD:1565242
See related
EnsemblRapid:ENSRNOG00000003428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ripx; Singar1
Expression
Biased expression in Brain (RPKM 230.2), Kidney (RPKM 118.4) and 9 other tissues See more
Orthologs
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Genomic context

See Rufy3 in Genome Data Viewer
Location:
14p22
Exon count:
25
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (19431530..19506531, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (21058575..21144775, complement)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 1B Neighboring gene G-rich RNA sequence binding factor 1 Neighboring gene microRNA 6321 Neighboring gene similar to microsomal glutathione S-transferase 3 Neighboring gene UTP3, small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein RUFY3
Names
RUN and FYVE domain-containing protein 3
rap2-interacting protein x
singar
singar2
single axon-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025127.1NP_001020298.1  protein RUFY3

    See identical proteins and their annotated locations for NP_001020298.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089952
    UniProtKB/Swiss-Prot
    Q5FVJ0
    Conserved Domains (2) summary
    COG1196
    Location:258464
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02759
    Location:103224
    RUN; RUN domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    19431530..19506531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770044.3XP_008768266.1  protein RUFY3 isoform X3

    Conserved Domains (4) summary
    cd15744
    Location:618664
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam01442
    Location:324497
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02759
    Location:153276
    RUN; RUN domain
    cl23720
    Location:390499
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_017599284.2XP_017454773.1  protein RUFY3 isoform X2

  3. XM_017599283.2XP_017454772.1  protein RUFY3 isoform X1

  4. XM_008770045.2XP_008768267.1  protein RUFY3 isoform X4

    Related
    ENSRNOP00000096851.1, ENSRNOT00000103075.1
    Conserved Domains (4) summary
    cd15744
    Location:611657
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam01442
    Location:324497
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02759
    Location:153276
    RUN; RUN domain
    cl23720
    Location:390499
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  5. XM_017599286.2XP_017454775.1  protein RUFY3 isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:290520
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15744
    Location:586632
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:121242
    RUN; RUN domain
  6. XM_039092170.1XP_038948098.1  protein RUFY3 isoform X5

    Related
    ENSRNOP00000020608.5, ENSRNOT00000020608.7
    Conserved Domains (3) summary
    COG1196
    Location:290520
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15744
    Location:586632
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:121242
    RUN; RUN domain
  7. XM_017599285.2XP_017454774.1  protein RUFY3 isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:290520
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15744
    Location:586632
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:121242
    RUN; RUN domain
  8. XM_006250781.4XP_006250843.1  protein RUFY3 isoform X6

    Conserved Domains (3) summary
    COG1196
    Location:272502
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15744
    Location:568614
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:103224
    RUN; RUN domain
  9. XM_006250783.4XP_006250845.1  protein RUFY3 isoform X8

    Related
    ENSRNOP00000004776.3, ENSRNOT00000004776.5
    Conserved Domains (4) summary
    cd15744
    Location:561607
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam01442
    Location:274447
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02759
    Location:103226
    RUN; RUN domain
    cl23720
    Location:340449
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  10. XM_039092171.1XP_038948099.1  protein RUFY3 isoform X6

    Related
    ENSRNOP00000073742.2, ENSRNOT00000092172.2
    Conserved Domains (3) summary
    COG1196
    Location:272502
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15744
    Location:568614
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:103224
    RUN; RUN domain
  11. XM_006250782.4XP_006250844.1  protein RUFY3 isoform X7

    Conserved Domains (4) summary
    cd15744
    Location:564610
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam01442
    Location:270443
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02759
    Location:99222
    RUN; RUN domain
    cl23720
    Location:336445
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  12. XM_008770046.3XP_008768268.1  protein RUFY3 isoform X9

    Conserved Domains (4) summary
    cd15744
    Location:559605
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam01442
    Location:265438
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02759
    Location:94217
    RUN; RUN domain
    cl23720
    Location:331440
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  13. XM_039092173.1XP_038948101.1  protein RUFY3 isoform X10

    Conserved Domains (3) summary
    COG1196
    Location:326532
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK07764
    Location:292
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam02759
    Location:171292
    RUN; RUN domain
  14. XM_008770047.2XP_008768269.1  protein RUFY3 isoform X11

    Related
    ENSRNOP00000093326.1, ENSRNOT00000100042.1
    Conserved Domains (3) summary
    COG1196
    Location:308514
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK07764
    Location:292
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam02759
    Location:153274
    RUN; RUN domain
  15. XM_008770048.3XP_008768270.1  protein RUFY3 isoform X12

    See identical proteins and their annotated locations for XP_008768270.1

    UniProtKB/Swiss-Prot
    Q5FVJ0
    Conserved Domains (1) summary
    pfam02759
    Location:121244
    RUN; RUN domain

RNA

  1. XR_001841024.2 RNA Sequence

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