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Marchf1 membrane associated ring-CH-type finger 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361135, updated on 5-Jun-2021

Summary

Symbol
Marchf1provided by RGD
Full Name
membrane associated ring-CH-type finger 1provided by RGD
Primary source
RGD:1305148
See related
Ensembl:ENSRNOG00000026310
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
March1; RGD1305148
Expression
Biased expression in Spleen (RPKM 150.6), Thymus (RPKM 36.7) and 7 other tissues See more
Orthologs
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Genomic context

See Marchf1 in Genome Data Viewer
Location:
16p14-p13
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (23255554..24114290, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (24998709..25856327, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene transketolase-like 2 Neighboring gene translation machinery associated 16 homolog Neighboring gene 60S ribosomal protein L22-like 1 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097418 Neighboring gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Neighboring gene U6 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene similar to mitochondrial ribosomal protein S25

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MHC protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antigen processing and presentation of peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antigen processing and presentation of peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCHF1
Names
E3 ubiquitin-protein ligase MARCH1
E3 ubiquitin-protein ligase MARCH1-like
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
NP_001129310.1
XP_008769356.3
XP_017455664.2
XP_017455665.2
XP_017455667.1
XP_017455668.1
XP_038950560.1
XP_038950561.1
XP_038950562.1
XP_038950563.1
XP_038950564.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135838.1NP_001129310.1  E3 ubiquitin-protein ligase MARCHF1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000279
    Related
    ENSRNOP00000038896.3, ENSRNOT00000032289.3
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    23255554..24114290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600176.2XP_017455665.2  E3 ubiquitin-protein ligase MARCHF1 isoform X3

    Conserved Domains (1) summary
    cd16698
    Location:332383
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  2. XM_039094632.1XP_038950560.1  E3 ubiquitin-protein ligase MARCHF1 isoform X1

    Conserved Domains (1) summary
    cd16698
    Location:332383
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  3. XM_017600179.2XP_017455668.1  E3 ubiquitin-protein ligase MARCHF1 isoform X2

    Conserved Domains (1) summary
    cd16698
    Location:328379
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  4. XM_039094634.1XP_038950562.1  E3 ubiquitin-protein ligase MARCHF1 isoform X2

    Conserved Domains (1) summary
    cd16698
    Location:328379
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  5. XM_008771134.3XP_008769356.3  E3 ubiquitin-protein ligase MARCHF1 isoform X6

    Conserved Domains (1) summary
    cd16698
    Location:79130
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  6. XM_039094635.1XP_038950563.1  E3 ubiquitin-protein ligase MARCHF1 isoform X4

    Conserved Domains (1) summary
    cd16698
    Location:79130
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  7. XM_039094636.1XP_038950564.1  E3 ubiquitin-protein ligase MARCHF1 isoform X5

    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  8. XM_039094633.1XP_038950561.1  E3 ubiquitin-protein ligase MARCHF1 isoform X2

    Conserved Domains (1) summary
    cd16698
    Location:328379
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  9. XM_017600178.2XP_017455667.1  E3 ubiquitin-protein ligase MARCHF1 isoform X2

    Conserved Domains (1) summary
    cd16698
    Location:328379
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  10. XM_017600175.2XP_017455664.2  E3 ubiquitin-protein ligase MARCHF1 isoform X1

    Conserved Domains (1) summary
    cd16698
    Location:332383
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
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