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Ercc6l2 ERCC excision repair 6 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361197, updated on 13-Apr-2024

Summary

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Official Symbol
Ercc6l2provided by RGD
Official Full Name
ERCC excision repair 6 like 2provided by RGD
Primary source
RGD:1561537
See related
Ensembl:ENSRNOG00000019175 AllianceGenome:RGD:1561537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561537
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in cellular response to reactive oxygen species and interstrand cross-link repair. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to colocalize with centrosome. Orthologous to human ERCC6L2 (ERCC excision repair 6 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 203.3), Thymus (RPKM 197.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17p14
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (1055881..1323207, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1076486..1311281, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1325654..1421732)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 367 Neighboring gene solute carrier family 35 member D2 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 3 Neighboring gene uncharacterized LOC102554174 Neighboring gene uncharacterized LOC134482763 Neighboring gene ribosomal protein L27a, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function. Tummala H, et al. Am J Hum Genet, 2014 Feb 6. PMID 24507776, Free PMC Article
  2. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. Vaz Meirelles G, et al. J Proteome Res, 2010 Dec 3. PMID 20873783
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA excision repair protein ERCC-6-like 2
Names
excision repair cross-complementation group 6-like 2
excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400699.1 → NP_001387628.1  DNA excision repair protein ERCC-6-like 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    D3ZPU4
    Related
    ENSRNOP00000025965.6, ENSRNOT00000025965.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    1055881..1323207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096261.2 → XP_038952189.1  DNA excision repair protein ERCC-6-like 2 isoform X4

    Conserved Domains (3) summary
    COG0553
    Location:9 → 649
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18005
    Location:122 → 369
    DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
    pfam14773
    Location:1132 → 1155
    VIGSSK; Helicase-associated putative binding domain, C-terminal

  2. XM_063276550.1 → XP_063132620.1  DNA excision repair protein ERCC-6-like 2 isoform X5

  3. XM_039096260.2 → XP_038952188.1  DNA excision repair protein ERCC-6-like 2 isoform X3

    Conserved Domains (3) summary
    COG0553
    Location:9 → 649
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18005
    Location:122 → 369
    DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
    pfam14773
    Location:1132 → 1155
    VIGSSK; Helicase-associated putative binding domain, C-terminal

  4. XM_039096259.2 → XP_038952187.1  DNA excision repair protein ERCC-6-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KQC8
    Conserved Domains (3) summary
    COG0553
    Location:9 → 649
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18005
    Location:122 → 369
    DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
    pfam14773
    Location:1132 → 1155
    VIGSSK; Helicase-associated putative binding domain, C-terminal

  5. XM_063276549.1 → XP_063132619.1  DNA excision repair protein ERCC-6-like 2 isoform X2

  6. XM_039096262.2 → XP_038952190.1  DNA excision repair protein ERCC-6-like 2 isoform X6

    Conserved Domains (2) summary
    cd18793
    Location:1 → 123
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    pfam14773
    Location:625 → 648
    VIGSSK; Helicase-associated putative binding domain, C-terminal

  7. XM_039096263.2 → XP_038952191.1  DNA excision repair protein ERCC-6-like 2 isoform X7

    Conserved Domains (2) summary
    COG0553
    Location:73 → 466
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cl28899
    Location:41 → 254
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RNA

  1. XR_010058894.1 RNA Sequence

  2. XR_010058892.1 RNA Sequence

  3. XR_010058893.1 RNA Sequence

  4. XR_005495504.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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