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Dtwd2 DTW domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361326, updated on 5-Mar-2024

Summary

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Official Symbol
Dtwd2provided by RGD
Official Full Name
DTW domain containing 2provided by RGD
Primary source
RGD:1306423
See related
Ensembl:ENSRNOG00000059142 AllianceGenome:RGD:1306423
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306423
Summary
Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to be located in cytoplasm and nucleus. Orthologous to human DTWD2 (DTW domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 35.5), Muscle (RPKM 34.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dtwd2 in Genome Data Viewer
Location:
18q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (45003242..45088595, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (42811783..42902040, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (43857371..43945732, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098276 Neighboring gene high-mobility group box 1, pseudogene 22 Neighboring gene tripartite motif-containing 28 protein-like Neighboring gene uncharacterized LOC120098148 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein L15, pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biogenesis and functions of aminocarboxypropyluridine in tRNA. Takakura M, et al. Nat Commun, 2019 Dec 5. PMID 31804502, Free PMC Article
  2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tRNA-uridine aminocarboxypropyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA-uridine aminocarboxypropyltransferase 2
Names
DTW domain-containing protein 2
NP_001101901.1
XP_006251070.1
XP_038952897.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108431.1 → NP_001101901.1  tRNA-uridine aminocarboxypropyltransferase 2

    See identical proteins and their annotated locations for NP_001101901.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473971
    UniProtKB/TrEMBL
    A6IWZ4, D3ZGK2
    Related
    ENSRNOP00000075130.2, ENSRNOT00000088900.2
    Conserved Domains (1) summary
    pfam03942
    Location:66 → 256
    DTW; DTW domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    45003242..45088595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096969.2 → XP_038952897.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A6IWZ5
    Conserved Domains (1) summary
    cl01221
    Location:66 → 142
    DTW; DTW domain

  2. XM_006251008.4 → XP_006251070.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    D3ZGK2
    Conserved Domains (1) summary
    pfam03942
    Location:66 → 198
    DTW; DTW domain

RNA

  1. XR_005496050.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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