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Cbfb core-binding factor subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 361391, updated on 5-Mar-2024

Summary

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Official Symbol
Cbfbprovided by RGD
Official Full Name
core-binding factor subunit betaprovided by RGD
Primary source
RGD:620493
See related
Ensembl:ENSRNOG00000014647 AllianceGenome:RGD:620493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pebp2
Summary
Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; protein polyubiquitination; and regulation of alpha-beta T cell differentiation. Predicted to act upstream of or within several processes, including hemopoiesis; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core-binding activity factor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 458.7), Spleen (RPKM 284.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (49955133..50002661)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33049162..33092752)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37127508..37171075)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L27, pseudogene 10 Neighboring gene phagosome assembly factor 1 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene TNFRSF1A-associated via death domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. Chen G, et al. J Neurochem, 1999 Feb. PMID 9930766
  2. RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries. Park ES, et al. Mol Endocrinol, 2010 Apr. PMID 20197312, Free PMC Article
  3. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. Yamamoto CM, et al. J Leukoc Biol, 2004 Feb. PMID 14634060
  4. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Liu P, et al. Science, 1993 Aug 20. PMID 8351518
  5. Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis. Miyagawa K, et al. Anticancer Res, 2006 Sep-Oct. PMID 17094378

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrated that proximity of the CAAT box and a putative polyoma enhancer-binding protein 2/core-binding factor PEBP2/CBF site was important for defensin NP-3 promoter activity.
    Title: Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
contributes_to sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within definitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of CD4-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of core-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
core-binding factor subunit beta
Names
core binding factor beta
core-binding factor, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013191.1 → NP_001013209.1  core-binding factor subunit beta

    See identical proteins and their annotated locations for NP_001013209.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081946
    UniProtKB/TrEMBL
    Q66HA7
    Related
    ENSRNOP00000019656.4, ENSRNOT00000019656.5
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 167
    CBF_beta; Core binding factor beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    49955133..50002661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255502.5 → XP_006255564.1  core-binding factor subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006255564.1

    UniProtKB/TrEMBL
    A0A8I5ZT73, A0A8I6GMB2, A6IYM1
    Related
    ENSRNOP00000097999.1
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 167
    CBF_beta; Core binding factor beta subunit

  2. XM_039097826.2 → XP_038953754.1  core-binding factor subunit beta isoform X2

    Conserved Domains (1) summary
    pfam02312
    Location:2 → 113
    CBF_beta; Core binding factor beta subunit

  3. XM_039097827.2 → XP_038953755.1  core-binding factor subunit beta isoform X3

    Conserved Domains (1) summary
    pfam02312
    Location:2 → 113
    CBF_beta; Core binding factor beta subunit
Nucleotide Protein Strain
Heading Accession and Version

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