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Ranbp10 RAN binding protein 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361396, updated on 30-Mar-2024

Summary

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Official Symbol
Ranbp10provided by RGD
Official Full Name
RAN binding protein 10provided by RGD
Primary source
RGD:1311587
See related
Ensembl:ENSRNOG00000018000 AllianceGenome:RGD:1311587
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311587
Summary
Predicted to enable beta-tubulin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in cell surface receptor signaling pathway and cytoskeleton organization. Predicted to act upstream of or within microtubule cytoskeleton organization. Predicted to be located in microtubule cytoskeleton. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RANBP10 (RAN binding protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 242.3), Thymus (RPKM 69.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50565924..50626720, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33656046..33716864, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37734662..37795360, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 2 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 2 Neighboring gene uncharacterized LOC134483349 Neighboring gene uncharacterized LOC108348930 Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. Schulze H, et al. J Biol Chem, 2008 May 16. PMID 18347012, Free PMC Article
  2. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Lampert F, et al. Elife, 2018 Jun 18. PMID 29911972, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ran-binding protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135875.1 → NP_001129347.1  ran-binding protein 10

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IYS3
    Conserved Domains (5) summary
    smart00667
    Location:285 → 312
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:319 → 375
    CTLH; C-terminal to LisH motif
    smart00757
    Location:535 → 632
    CRA; CT11-RanBPM
    pfam10607
    Location:319 → 373
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:105 → 247
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50565924..50626720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278126.1 → XP_063134196.1  ran-binding protein 10 isoform X3

  2. XM_039097833.2 → XP_038953761.1  ran-binding protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AKP2
    Conserved Domains (4) summary
    smart00667
    Location:299 → 326
    LisH; Lissencephaly type-1-like homology motif
    smart00757
    Location:565 → 662
    CRA; CT11-RanBPM
    pfam10607
    Location:333 → 387
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cl02614
    Location:175 → 261
    SPRY; SPRY domain

  3. XM_017601317.3 → XP_017456806.2  ran-binding protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AKP2, D3Z7Z5
    Related
    ENSRNOP00000024891.6
    Conserved Domains (4) summary
    smart00667
    Location:355 → 382
    LisH; Lissencephaly type-1-like homology motif
    smart00757
    Location:621 → 718
    CRA; CT11-RanBPM
    cd12909
    Location:175 → 317
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
    pfam10607
    Location:389 → 443
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  4. XM_039097835.2 → XP_038953763.1  ran-binding protein 10 isoform X5

    Conserved Domains (4) summary
    smart00667
    Location:126 → 153
    LisH; Lissencephaly type-1-like homology motif
    smart00757
    Location:392 → 489
    CRA; CT11-RanBPM
    pfam10607
    Location:160 → 214
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cl02614
    Location:4 → 88
    SPRY; SPRY domain

  5. XM_039097834.2 → XP_038953762.1  ran-binding protein 10 isoform X4

    Conserved Domains (3) summary
    smart00667
    Location:355 → 382
    LisH; Lissencephaly type-1-like homology motif
    cd12909
    Location:175 → 317
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
    pfam10607
    Location:389 → 443
    CLTH; CTLH/CRA C-terminal to LisH motif domain
Nucleotide Protein Strain
Heading Accession and Version

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