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CG12325 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36144, updated on 4-Apr-2024

Summary

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Official Symbol
CG12325provided by FlyBase
Primary source
FLYBASE:FBgn0033557
Locus tag
Dmel_CG12325
See related
AllianceGenome:FB:FBgn0033557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12325
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in spermatozoon. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
47C1-47C1; 2-63 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10823405..10827644)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6710910..6715149)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S15Ab Neighboring gene uncharacterized protein Neighboring gene alkaliphile Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
  2. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
  3. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article
  4. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article
  5. Transcription factor networks in Drosophila melanogaster. Rhee DY, et al. Cell Rep, 2014 Sep 25. PMID 25242320, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12325-PA
CG12325-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10823405..10827644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299367.1 → NP_001286296.1  uncharacterized protein Dmel_CG12325, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U0X8
    Conserved Domains (5) summary
    COG2319
    Location:16 → 483
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:352 → 605
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04003
    Location:794 → 893
    Utp12; Dip2/Utp12 Family
    sd00039
    Location:353 → 391
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:98 → 463
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_136774.2 → NP_610618.1  uncharacterized protein Dmel_CG12325, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610618.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U0X8
    Related
    FBpp0087322
    Conserved Domains (5) summary
    COG2319
    Location:16 → 483
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:352 → 605
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04003
    Location:794 → 893
    Utp12; Dip2/Utp12 Family
    sd00039
    Location:353 → 391
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:98 → 463
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U0X8 Q5U0X8

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