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Hddc2 HD domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361462, updated on 5-Mar-2024

Summary

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Official Symbol
Hddc2provided by RGD
Official Full Name
HD domain containing 2provided by RGD
Primary source
RGD:1307562
See related
Ensembl:ENSRNOG00000021442 AllianceGenome:RGD:1307562
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307562
Summary
Predicted to enable 5'-deoxynucleotidase activity. Predicted to be involved in dephosphorylation. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 79.2), Muscle (RPKM 63.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (28100669..28133008, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (26294030..26313914, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (28567447..28600116, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 217 Neighboring gene uncharacterized LOC134484976 Neighboring gene TPD52 like 1 Neighboring gene uncharacterized LOC134484854 Neighboring gene SEC24 homolog C, COPII coat complex component, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-deoxynucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5'-deoxynucleotidase HDDC2
Names
HD domain-containing protein 2
NP_001101930.1
XP_038937096.1
XP_063122124.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108460.1 → NP_001101930.1  5'-deoxynucleotidase HDDC2

    See identical proteins and their annotated locations for NP_001101930.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474002
    UniProtKB/TrEMBL
    A6JUR8, D3ZKT8
    Related
    ENSRNOP00000034339.4, ENSRNOT00000029444.7
    Conserved Domains (1) summary
    pfam13023
    Location:19 → 175
    HD_3; HD domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    28100669..28133008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266054.1 → XP_063122124.1  5'-deoxynucleotidase HDDC2 isoform X1

  2. XM_039081168.2 → XP_038937096.1  5'-deoxynucleotidase HDDC2 isoform X2

    Conserved Domains (1) summary
    pfam13023
    Location:1 → 131
    HD_3; HD domain
Nucleotide Protein Strain
Heading Accession and Version

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