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Prodh2 proline dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361538, updated on 11-Apr-2024

Summary

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Official Symbol
Prodh2provided by RGD
Official Full Name
proline dehydrogenase 2provided by RGD
Primary source
RGD:1306761
See related
Ensembl:ENSRNOG00000057578 AllianceGenome:RGD:1306761
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HYPDH
Summary
Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be active in mitochondrion. Orthologous to human PRODH2 (proline dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 644.5), Kidney (RPKM 494.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94881000..94894609)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85753558..85767165)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88955125..88968501)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 2 Neighboring gene NPHS1 adhesion molecule, nephrin Neighboring gene similar to Gene model 1082 Neighboring gene Rho GTPase activating protein 33 Neighboring gene uncharacterized LOC120097050

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. Summitt CB, et al. Biochem J, 2015 Mar 1. PMID 25697095, Free PMC Article
  2. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-NH group of donors ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-NH group of donors ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proline dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proline catabolic process to glutamate IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hydroxyproline dehydrogenase
Names
probable proline dehydrogenase 2
probable proline oxidase 2
proline dehydrogenase (oxidase) 2
proline oxidase-like protein
NP_001033677.1
XP_038937824.1
XP_063122494.1
XP_063122496.1
XP_063122505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038588.1 → NP_001033677.1  hydroxyproline dehydrogenase

    See identical proteins and their annotated locations for NP_001033677.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158806
    UniProtKB/Swiss-Prot
    Q2V057
    UniProtKB/TrEMBL
    A0A0G2K5H0, B0BNG1
    Related
    ENSRNOP00000073423.2, ENSRNOT00000083550.2
    Conserved Domains (2) summary
    PLN02681
    Location:28 → 453
    PLN02681; proline dehydrogenase
    pfam01619
    Location:218 → 439
    Pro_dh; Proline dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94881000..94894609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266426.1 → XP_063122496.1  hydroxyproline dehydrogenase isoform X2

  2. XM_063266424.1 → XP_063122494.1  hydroxyproline dehydrogenase isoform X1

  3. XM_063266435.1 → XP_063122505.1  hydroxyproline dehydrogenase isoform X4

  4. XM_039081896.2 → XP_038937824.1  hydroxyproline dehydrogenase isoform X3

    Conserved Domains (1) summary
    cl40683
    Location:8 → 256
    Pro_dh; Proline dehydrogenase

RNA

  1. XR_005487888.2 RNA Sequence

  2. XR_005487887.2 RNA Sequence

  3. XR_005487885.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2V057.1 GenPept UniProtKB/Swiss-Prot:Q2V057

Gene LinkOut

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